Derivation Web · source_f7958856b18f4cb4

source · application/json

source_f7958856b18f4cb4

sha256 6ce59187529fe1d94cecee9ee726dba0a791f877232d4230bcf0c88877f50169

by researka:v2 · 2026-06-28 04:45:41.659310+04:00

{"publication_id": "054f72de-a886-4506-a529-11d92344f009", "traces": [{"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "This synthesis tests the thesis that evidence for Telomere Cancer Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "This paper synthesizes evidence on telomere cancer effects across 25 included source papers and 826 high-confidence extracted claims.", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "The evidence profile contains no sources classified primarily as direct interventional hard-endpoint evidence, 24 adjacent clinical sources, and 1 mechanistic or model-system source, with 3 cross-study disagreements across the evidence base.", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Positive study-level signals are summarized in the frailty outcome class; null signals are summarized in the immune and inflammation and mechanism outcome classes; negative signals are summarized in the dosing and pharmacokinetics outcome class; mixed or heterogeneous signals are summarized in the contextual adjacent evidence, mortality and survival, and longevity outcome classes. The paper therefore reports a source-directness and outcome-class map rather than a pooled effect.", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "The conclusion is narrower: the retained evidence maps associations, mechanisms, and candidate endpoints for follow-up; it does not establish clinical benefit, therapeutic actionability, or anti-aging efficacy.", "claim_id": "claim_6"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "For Telomere Cancer Effects, what does the retained evidence show about prognostic or risk-marker associations, causal or mechanistic evidence, treatment or intervention relevance across prognostic and survival-marker evidence, treatment or intervention-response evidence, causal-risk and Mendelian-randomization evidence, and are those outcome-class source-level signals directionally consistent enough for clinical actionability once unclear direction coding, adjacent/contextual source roles, and directness limits are considered?", "claim_id": "claim_7"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-telomere_cancer_effects-v06-DAILY-2026-06-28T00-39-28Z`.", "claim_id": "claim_8"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_9"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "claim_id": "claim_10"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (contextual adjacent evidence, dosing and pharmacokinetics, frailty, immune and inflammation, longevity, mechanism, mortality and survival); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_11"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_12"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Source directness breakdown: 0/25 retained sources directly address the stated topic and aging-relevant hard endpoints; 25/25 are adjacent, contextual, review-level, or mechanistic and are used only to bound interpretation. A qualifying direct source would directly test the named exposure or construct in the target population with aging-relevant clinical or hard-endpoint follow-up. Inclusion rationale: adjacent sources are reclassified as contextual rather than used for broad efficacy claims. Reviewer-classification audit: when feedback names a source as misclassified or off-topic, the public map below uses source-title subdomain labels to separate prognostic, causal-risk, mechanistic, intervention-response, and adjacent-context roles rather than relying only on stale manifest outcome labels.", "claim_id": "claim_13"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Alhareeri 2020: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "claim_id": "claim_14"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Jaeger 2024: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "claim_id": "claim_15"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Markozannes 2022: outcome=Immune and Inflammation; direction=null; directness=review; tier=B2.", "claim_id": "claim_16"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.37349/etat.2025.1002289"}, {"directness": "primary", "doi": "10.1186/s13058-020-01368-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13058-020-01368-6"}, {"directness": "primary", "doi": "10.3390/nu16172963", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/nu16172963"}, {"directness": "primary", "doi": "10.1186/s13148-026-02137-6", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s13148-026-02137-6"}, {"directness": "review-level", "doi": "10.1186/s12916-022-02246-y", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Systematic review of Mendelian randomization studies on risk of cancer", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12916-022-02246-y"}], "claim": "Li 2026: outcome=Contextual Adjacent Evidence; 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