source · application/json
source_f8c98783dfea484e
sha256 48dd7dbbbd1d6d5d18e4907798b3addf1401262f77557ce7d1b1343a9dcfc87c
by researka:v2 · 2026-06-06 04:10:44.870963+04:00
{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "79d2cfdb-60fe-4786-be4f-b55cacadc266", "sources": [{"directness": "primary", "doi": "10.3390/cimb47080642", "risk_of_bias": "not appraised in public sidecar", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model"}, {"directness": "primary", "doi": "10.1152/function.109.2025", "risk_of_bias": "not appraised in public sidecar", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy"}, {"directness": "primary", "doi": "10.3390/jcm12216866", "risk_of_bias": "not appraised in public sidecar", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study"}, {"directness": "primary", "doi": "10.1038/s41405-025-00370-4", "risk_of_bias": "not appraised in public sidecar", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration"}, {"directness": "primary", "doi": "10.1038/s42003-022-03563-x", "risk_of_bias": "not appraised in public sidecar", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes"}, {"directness": "primary", "doi": "10.1186/s12933-024-02369-x", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of extracellular matrix stiffness on efficacy of Dapagliflozin for diabetic cardiomyopathy"}, {"directness": "primary", "doi": "10.1038/s44161-023-00348-1", "risk_of_bias": "not appraised in public sidecar", "study": "Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix"}, {"directness": "primary", "doi": "10.3390/ijms26073128", "risk_of_bias": "not appraised in public sidecar", "study": "The Presence of Adipose Tissue in Aortic Valves Influences Inflammation and Extracellular Matrix Composition in Chronic Aortic Regurgitation"}, {"directness": "primary", "doi": "10.1097/HC9.0000000000000564", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction"}, {"directness": "primary", "doi": "10.3390/antiox12030679", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation"}, {"directness": "primary", "doi": "10.1093/burnst/tkad002", "risk_of_bias": "not appraised in public sidecar", "study": "Adjusting the stiffness of a cell-free hydrogel system based on tissue-specific extracellular matrix to optimize adipose tissue regeneration"}, {"directness": "primary", "doi": "10.1186/s40164-025-00704-w", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter"}, {"directness": "primary", "doi": "10.3390/cancers18101652", "risk_of_bias": "not appraised in public sidecar", "study": "A Vascular–Extracellular Matrix Molecular Program Identifies High-Risk Diffuse Glioma Across Independent Multi-Omics"}, {"directness": "primary", "doi": "10.3390/ph17050644", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular Matrix Stiffness-Induced Mechanotransduction of Capillarized Liver Sinusoidal Endothelial Cells"}, {"directness": "primary", "doi": "10.3389/fcell.2022.844342", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular Matrix Stiffness and TGFβ2 Regulate YAP/TAZ Activity in Human Trabecular Meshwork Cells"}, {"directness": "primary", "doi": "10.1038/s41467-025-59252-w", "risk_of_bias": "not appraised in public sidecar", "study": "Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease"}, {"directness": "review-level", "doi": "10.1186/s13018-025-05881-2", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy of decellularized extracellular matrix (dECM) for articular cartilage repair in osteoarthritis (OA): a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1038/s41598-023-41584-6", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness aggravates urethral stricture through Igfbp3/Smad pathway"}, {"directness": "primary", "doi": "10.3389/fcell.2024.1381470", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of aging on the biomechanical properties of the lung extracellular matrix: dependence on tissular stretch"}, {"directness": "primary", "doi": "10.1038/s41413-025-00495-0", "risk_of_bias": "not appraised in public sidecar", "study": "Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging"}, {"directness": "primary", "doi": "10.1073/pnas.2304288120", "risk_of_bias": "not appraised in public sidecar", "study": "Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling"}, {"directness": "primary", "doi": "10.3390/jcm15031177", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular Matrix Tissue Patch for Pulmonary Artery Repair in Pediatric Cardiac Surgery: A Single-Center Experience"}, {"directness": "primary", "doi": "10.1158/1078-0432.CCR-25-1098", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular Matrix–MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC"}, {"directness": "primary", "doi": "10.1002/adhm.202203044", "risk_of_bias": "not appraised in public sidecar", "study": "3D Printing of Extracellular Matrix‐Based Multicomponent, All‐Natural, Highly Elastic, and Functional Materials toward Vascular Tissue Engineering"}, {"directness": "primary", "doi": "10.1177/20417314221074453", "risk_of_bias": "not appraised in public sidecar", "study": "Preservation of the naïve features of mesenchymal stromal cells in vitro: Comparison of cell- and bone-derived decellularized extracellular matrix"}, {"directness": "primary", "doi": "10.18502/ijph.v51i11.11166", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of miRNA-218-5p on Proliferation, Migration, Apoptosis and Inflammation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm and Extracellular Matrix Protein"}, {"directness": "primary", "doi": "10.1111/acel.13966", "risk_of_bias": "not appraised in public sidecar", "study": "In need of age‐appropriate cardiac models: Impact of cell age on extracellular matrix therapy outcomes"}, {"directness": "primary", "doi": "10.3390/cancers14010259", "risk_of_bias": "not appraised in public sidecar", "study": "Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence"}, {"directness": "review-level", "doi": "10.3389/fcvm.2025.1532157", "risk_of_bias": "not appraised in public sidecar", "study": "Tissue response and clinical outcomes after cardiovascular use of porcine small intestinal small intestinal submucosal extracellular matrix: a systematic review"}, {"directness": "primary", "doi": "10.3390/biomedicines11020241", "risk_of_bias": "not appraised in public sidecar", "study": "Association of Epicardial Adipose Tissue Adipocytes Hypertrophy with Biomarkers of Low-Grade Inflammation and Extracellular Matrix Remodeling in Patients with Coronary Artery Disease"}, {"directness": "primary", "doi": "10.1063/5.0157549", "risk_of_bias": "not appraised in public sidecar", "study": "Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells"}, {"directness": "primary", "doi": "10.1242/jcs.260636", "risk_of_bias": "not appraised in public sidecar", "study": "Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3"}, {"directness": "primary", "doi": "10.1097/CM9.0000000000003409", "risk_of_bias": "not appraised in public sidecar", "study": "Suppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse"}, {"directness": "primary", "doi": "10.3390/jcm14113955", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular Matrix Tissue Patch for Aortic Arch Repair in Pediatric Cardiac Surgery: A Single-Center Experience"}, {"directness": "primary", "doi": "10.1186/s13046-025-03297-8", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness regulates colorectal cancer progression via HSF4"}, {"directness": "primary", "doi": "10.1161/CIRCRESAHA.123.323365", "risk_of_bias": "not appraised in public sidecar", "study": "Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness"}, {"directness": "primary", "doi": "10.1111/jcmm.70025", "risk_of_bias": "not appraised in public sidecar", "study": "CD248 ‐expressing cancer‐associated fibroblasts induce non‐small cell lung cancer metastasis via Hippo pathway‐mediated extracellular matrix stiffness"}, {"directness": "primary", "doi": "10.1007/s11626-023-00803-0", "risk_of_bias": "not appraised in public sidecar", "study": "Ecliptasaponin A attenuates renal fibrosis by regulating the extracellular matrix of renal tubular cells"}, {"directness": "primary", "doi": "10.1111/acel.70474", "risk_of_bias": "not appraised in public sidecar", "study": "An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease"}, {"directness": "primary", "doi": "10.1038/s41419-025-07697-8", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis"}, {"directness": "primary", "doi": "10.1002/advs.202509846", "risk_of_bias": "not appraised in public sidecar", "study": "Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling"}, {"directness": "primary", "doi": "10.1155/2023/1381620", "risk_of_bias": "not appraised in public sidecar", "study": "Retinal Progenitor Cells Exhibit Cadherin-Dependent Chemotaxis across Transplantable Extracellular Matrix of In Vitro Developmental and Adult Models"}, {"directness": "primary", "doi": "10.1186/s12964-022-01018-8", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness mediates uterine repair via the Rap1a/ARHGAP35/RhoA/F-actin/YAP axis"}, {"directness": "primary", "doi": "10.1155/2024/6632276", "risk_of_bias": "not appraised in public sidecar", "study": "Varying Properties of Extracellular Matrix Grafts Impact Their Durability and Cell Attachment and Proliferation in an In Vitro Chronic Wound Model"}, {"directness": "primary", "doi": "10.3390/ijms24021708", "risk_of_bias": "not appraised in public sidecar", "study": "Multi-Step Extracellular Matrix Remodelling and Stiffening in the Development of Idiopathic Pulmonary Fibrosis"}, {"directness": "primary", "doi": "10.1111/acel.13746", "risk_of_bias": "not appraised in public sidecar", "study": "Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization"}, {"directness": "primary", "doi": "10.1177/20417314241268344", "risk_of_bias": "not appraised in public sidecar", "study": "Two-dimensional vascularized liver organoid on extracellular matrix with defined stiffness for modeling fibrotic and normal tissues"}, {"directness": "primary", "doi": "10.1038/s41598-025-27140-4", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness modulates angiogenic properties of the retinal pigment epithelium"}, {"directness": "primary", "doi": "10.3390/ijms232415953", "risk_of_bias": "not appraised in public sidecar", "study": "Spatio-Temporal Changes of Extracellular Matrix (ECM) Stiffness in the Development of the Leech Hirudo verbana"}, {"directness": "primary", "doi": "10.3390/biology13080636", "risk_of_bias": "not appraised in public sidecar", "study": "Assessment of Extracellular Matrix Fibrous Elements in Male Dermal Aging: A Ten-Year Follow-Up Preliminary Case Study"}, {"directness": "primary", "doi": "10.3389/fphys.2021.804188", "risk_of_bias": "not appraised in public sidecar", "study": "The Contributions of Extracellular Matrix and Sarcomere Properties to Passive Muscle Stiffness in Cerebral Palsy"}, {"directness": "primary", "doi": "10.1002/SMMD.20240026", "risk_of_bias": "not appraised in public sidecar", "study": "Change in p53 nuclear localization in response to extracellular matrix stiffness"}, {"directness": "primary", "doi": "10.1002/btm2.10518", "risk_of_bias": "not appraised in public sidecar", "study": "Adjustable extracellular matrix rigidity tumor model for studying stiffness dependent pancreatic ductal adenocarcinomas progression and tumor immunosuppression"}, {"directness": "primary", "doi": "10.13107/jocr.2026.v16.i05.7228", "risk_of_bias": "not appraised in public sidecar", "study": "Tibialis Anterior Muscle Herniation Managed with Ovine Extracellular Matrix Patch: Case Report"}, {"directness": "primary", "doi": "10.3390/antibiotics14090885", "risk_of_bias": "not appraised in public sidecar", "study": "Utilization of a Multi-Tissue Extracellular Matrix in Complex Wound Care in Gaza: A Case Series"}, {"directness": "primary", "doi": "10.3390/ijms26189182", "risk_of_bias": "not appraised in public sidecar", "study": "COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair"}, {"directness": "primary", "doi": "10.3390/biom14121493", "risk_of_bias": "not appraised in public sidecar", "study": "A Versatile Skin-Derived Extracellular Matrix Hydrogel-Based Platform to Investigate the Function of a Mechanically Isolated Adipose Tissue Stromal Vascular Fraction"}, {"directness": "primary", "doi": "10.1371/journal.pone.0294955", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethral stricture disease"}, {"directness": "primary", "doi": "10.3389/fcell.2023.1292775", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}
metadata
{
"researka_object_type": "publication_sidecar",
"researka_publication_id": "79d2cfdb-60fe-4786-be4f-b55cacadc266",
"researka_submission_id": "ca33ca55-467b-41c9-b22d-473853ddf6df",
"sidecar_name": "risk_of_bias.json",
"sidecar_url": "https://api.researka.org/publications/79d2cfdb-60fe-4786-be4f-b55cacadc266/sidecars/risk_of_bias.json"
}