Derivation Web

source_fa0fc892944a47bd

by researka:v2 · 2026-06-02 15:29:30.082071+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "ec49b21a-665d-471c-b2c4-8ab5a5943e34", "sources": [{"directness": "primary", "doi": "10.1111/acel.70114", "risk_of_bias": "not appraised in public sidecar", "study": "Murray 2025"}, {"directness": "primary", "doi": "10.1016/j.jnha.2025.100529", "risk_of_bias": "not appraised in public sidecar", "study": "Mielke 2025"}, {"directness": "primary", "doi": "10.1038/s43587-024-00663-7", "risk_of_bias": "not appraised in public sidecar", "study": "Zumerle 2024"}, {"directness": "primary", "doi": "10.1111/acel.70108", "risk_of_bias": "not appraised in public sidecar", "study": "Mury 2025"}, {"directness": "primary", "doi": "10.3390/foods13223668", "risk_of_bias": "not appraised in public sidecar", "study": "Zhao 2024"}, {"directness": "primary", "doi": "10.1186/s12967-025-07108-8", "risk_of_bias": "not appraised in public sidecar", "study": "Zhang 2025"}, {"directness": "review-level", "doi": "10.3390/nu14173476", "risk_of_bias": "not appraised in public sidecar", "study": "Giudice 2022"}, {"directness": "primary", "doi": "10.1007/s11357-022-00685-2", "risk_of_bias": "not appraised in public sidecar", "study": "Fielding 2022"}, {"directness": "primary", "doi": "10.1186/s12967-024-05814-3", "risk_of_bias": "not appraised in public sidecar", "study": "Sun 2024"}, {"directness": "review-level", "doi": "10.3389/fendo.2024.1336357", "risk_of_bias": "not appraised in public sidecar", "study": "Ju 2024"}, {"directness": "primary", "doi": "10.1080/0886022X.2026.2628471", "risk_of_bias": "not appraised in public sidecar", "study": "Li 2026"}, {"directness": "review-level", "doi": "10.1186/s12877-026-07025-5", "risk_of_bias": "not appraised in public sidecar", "study": "Sanchez-Romero 2026"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.19678", "risk_of_bias": "not appraised in public sidecar", "study": "Diniz 2022"}, {"directness": "review-level", "doi": "10.3389/fimmu.2025.1570441", "risk_of_bias": "not appraised in public sidecar", "study": "Rastgoo 2025"}, {"directness": "primary", "doi": "10.1186/s12931-024-02790-6", "risk_of_bias": "not appraised in public sidecar", "study": "Wan 2024"}, {"directness": "primary", "doi": "10.7554/eLife.101702", "risk_of_bias": "not appraised in public sidecar", "study": "Bartlett 2024"}, {"directness": "review-level", "doi": "10.3390/ijms242115617", "risk_of_bias": "not appraised in public sidecar", "study": "Veronesi 2023"}, {"directness": "primary", "doi": "10.1111/1365-2656.13842", "risk_of_bias": "not appraised in public sidecar", "study": "Rotger 2023"}, {"directness": "primary", "doi": "10.3390/ijms232214006", "risk_of_bias": "not appraised in public sidecar", "study": "Picca 2022"}, {"directness": "primary", "doi": "10.1093/rheumatology/keae660", "risk_of_bias": "not appraised in public sidecar", "study": "Chiu 2024"}, {"directness": "primary", "doi": "10.3390/ijms27104406", "risk_of_bias": "not appraised in public sidecar", "study": "Blomquist 2026"}, {"directness": "primary", "doi": "10.1111/acel.13936", "risk_of_bias": "not appraised in public sidecar", "study": "Petrocelli 2023"}, {"directness": "primary", "doi": "10.1186/s12929-024-01064-z", "risk_of_bias": "not appraised in public sidecar", "study": "Lara-Aguilar 2024"}, {"directness": "review-level", "doi": "10.18632/aging.204458", "risk_of_bias": "not appraised in public sidecar", "study": "Chen 2022"}, {"directness": "review-level", "doi": "10.1016/j.clinsp.2025.100586", "risk_of_bias": "not appraised in public sidecar", "study": "Neves 2025"}, {"directness": "primary", "doi": "10.1111/dme.70059", "risk_of_bias": "not appraised in public sidecar", "study": "Shah 2025"}, {"directness": "review-level", "doi": "10.3389/fragi.2024.1500741", "risk_of_bias": "not appraised in public sidecar", "study": "Miller 2024"}, {"directness": "primary", "doi": "10.1038/s41598-022-23950-y", "risk_of_bias": "not appraised in public sidecar", "study": "Nguyen 2022"}, {"directness": "primary", "doi": "10.1038/s41586-022-05535-x", "risk_of_bias": "not appraised in public sidecar", "study": "Moiseeva 2022"}, {"directness": "primary", "doi": "10.1007/s00414-023-02954-x", "risk_of_bias": "not appraised in public sidecar", "study": "San-Millan 2023"}, {"directness": "review-level", "doi": "10.1186/s13287-025-04767-8", "risk_of_bias": "not appraised in public sidecar", "study": "Morita 2025"}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1566227", "risk_of_bias": "not appraised in public sidecar", "study": "Liu 2025"}, {"directness": "review-level", "doi": "10.3389/fimmu.2024.1326922", "risk_of_bias": "not appraised in public sidecar", "study": "Yang 2024"}, {"directness": "primary", "doi": "10.1038/s41586-023-06621-4", "risk_of_bias": "not appraised in public sidecar", "study": "Victorelli 2023"}, {"directness": "review-level", "doi": "10.3390/cells12242824", "risk_of_bias": "not appraised in public sidecar", "study": "Malvaso 2023"}, {"directness": "primary", "doi": "10.3389/fendo.2023.1255889", "risk_of_bias": "not appraised in public sidecar", "study": "Fang 2023"}, {"directness": "primary", "doi": "10.1155/2022/5628946", "risk_of_bias": "not appraised in public sidecar", "study": "Huang 2022"}, {"directness": "review-level", "doi": "10.3390/ijms27031520", "risk_of_bias": "not appraised in public sidecar", "study": "Sobolewski 2026"}, {"directness": "primary", "doi": "10.1186/s12974-023-02870-2", "risk_of_bias": "not appraised in public sidecar", "study": "Ocanas 2023"}, {"directness": "primary", "doi": "10.3390/biom13040686", "risk_of_bias": "not appraised in public sidecar", "study": "Silwal 2023"}, {"directness": "primary", "doi": "10.1155/2023/6641347", "risk_of_bias": "not appraised in public sidecar", "study": "Mukem 2023"}, {"directness": "primary", "doi": "10.3389/fgene.2024.1461404", "risk_of_bias": "not appraised in public sidecar", "study": "Liu 2025b"}, {"directness": "review-level", "doi": "10.3389/fragi.2025.1543360", "risk_of_bias": "not appraised in public sidecar", "study": "Ebrahimirad 2025"}, {"directness": "primary", "doi": "10.3389/fmicb.2025.1623875", "risk_of_bias": "not appraised in public sidecar", "study": "Huang 2025"}, {"directness": "primary", "doi": "10.3390/ijms24043755", "risk_of_bias": "not appraised in public sidecar", "study": "Liu 2023"}, {"directness": "primary", "doi": "10.1371/journal.pbio.0060301", "risk_of_bias": "not appraised in public sidecar", "study": "Coppe 2008"}, {"directness": "primary", "doi": "10.1083/jcb.201009094", "risk_of_bias": "not appraised in public sidecar", "study": "Rodier 2011"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "ec49b21a-665d-471c-b2c4-8ab5a5943e34",
  "researka_submission_id": "71a22306-f5c6-4a2c-9e34-dde82a8ed52a",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/ec49b21a-665d-471c-b2c4-8ab5a5943e34/sidecars/risk_of_bias.json"
}