Derivation Web

source_fa7e109cc49e47b2

by researka:v2 · 2026-06-24 19:38:07.789300+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f2d5e407-7f5f-4de0-8775-b05423c0edb8", "sources": [{"directness": "primary", "doi": "10.1038/s43587-024-00612-4", "risk_of_bias": "not appraised in public sidecar", "study": "Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism"}, {"directness": "primary", "doi": "10.3390/brainsci14070656", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Young Plasma Therapy on Cognition, Oxidative Stress, miRNA-134, BDNF, CREB, and SIRT-1 Expressions and Neuronal Survey in the Hippocampus of Aged Ovariectomized Rats with Alzheimer’s"}, {"directness": "primary", "doi": "10.1186/s13195-020-00639-w", "risk_of_bias": "not appraised in public sidecar", "study": "Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice"}, {"directness": "primary", "doi": "10.1111/jcmm.17926", "risk_of_bias": "not appraised in public sidecar", "study": "The rejuvenating influence of young plasma on aged intestine"}, {"directness": "primary", "doi": "10.3389/fnagi.2022.996223", "risk_of_bias": "not appraised in public sidecar", "study": "Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity"}, {"directness": "primary", "doi": "10.1007/s10522-025-10260-9", "risk_of_bias": "not appraised in public sidecar", "study": "Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosis"}, {"directness": "primary", "doi": "10.22038/IJBMS.2023.72437.15754", "risk_of_bias": "not appraised in public sidecar", "study": "Chronic stress-induced anxiety-like behavior, hippocampal oxidative, and endoplasmic reticulum stress are reversed by young plasma transfusion in aged adult rats"}, {"directness": "primary", "doi": "10.1007/s10522-025-10204-3", "risk_of_bias": "not appraised in public sidecar", "study": "Rejuvenating the gut: young plasma therapy improves cell proliferation, IGF-I and IGF-IR expression, and immune defense in aged male rats jejunum"}, {"directness": "primary", "doi": "10.14336/AD.2023.1230", "risk_of_bias": "not appraised in public sidecar", "study": "Young Plasma Attenuated Chronic Kidney Disease Progression after Acute Kidney Injury by Inhibiting Inflammation in Mice"}, {"directness": "primary", "doi": "10.21037/atm-20-8008", "risk_of_bias": "not appraised in public sidecar", "study": "Young plasma attenuates cognitive impairment and the cortical hemorrhage area in cerebral amyloid angiopathy model mice"}, {"directness": "primary", "doi": "10.1093/gerona/glae071", "risk_of_bias": "not appraised in public sidecar", "study": "Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance in Old Rats"}, {"directness": "primary", "doi": "10.1002/mds.28198", "risk_of_bias": "not appraised in public sidecar", "study": "Safety of Plasma Infusions in Parkinson's Disease"}, {"directness": "primary", "doi": "10.3389/fbioe.2024.1408499", "risk_of_bias": "not appraised in public sidecar", "study": "A simple cell proliferation assay and the inflammatory protein content show significant differences in human plasmas from young and old subjects"}, {"directness": "primary", "doi": "10.1016/j.bioactmat.2025.03.012", "risk_of_bias": "not appraised in public sidecar", "study": "Exosomes from young plasma stimulate the osteogenic differentiation and prevent osteoporosis via miR-142-5p"}, {"directness": "review-level", "doi": "10.1093/gerona/glag007", "risk_of_bias": "not appraised in public sidecar", "study": "Young plasma transfer enhances antioxidant defense and preserves structural integrity in aged lung tissue."}, {"directness": "primary", "doi": "10.1042/BSR20190537", "risk_of_bias": "not appraised in public sidecar", "study": "Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage"}, {"directness": "primary", "doi": "10.1111/acel.12708", "risk_of_bias": "not appraised in public sidecar", "study": "Young plasma reverses age‐dependent alterations in hepatic function through the restoration of autophagy"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.1093/ageing/26.1.15", "risk_of_bias": "not appraised in public sidecar", "study": "Bohannon 1997"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "f2d5e407-7f5f-4de0-8775-b05423c0edb8",
  "researka_submission_id": "8a5f6496-b051-4174-82d4-7bf7a1998b4b",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/f2d5e407-7f5f-4de0-8775-b05423c0edb8/sidecars/risk_of_bias.json"
}