Derivation Web

source_faa419ffaa8e4c8a

by researka:v2 · 2026-06-24 08:46:03.764602+04:00

{"content_hash": null, "edges": [{"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_1", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_2", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_3", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_4", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_5", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_6", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_7", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_8", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_9", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_10", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_11", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_12", "type": "contains_claim"}], "nodes": [{"id": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "title": "mtor: receipt-backed evidence fronts", "type": "publication"}, {"id": "claim_1", "text": "Across retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "type": "claim"}, {"id": "claim_2", "text": "Finding: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10", "type": "claim"}, {"id": "claim_3", "text": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. [primary; 2013] doi:10.1016/j.celrep.2013.07.030", "type": "claim"}, {"id": "claim_4", "text": "Finding: Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.", "type": "claim"}, {"id": "claim_5", "text": "This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).", "type": "claim"}, {"id": "claim_6", "text": "other/mixed: International consensus on post-transplantation diabetes mellitus — observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10", "type": "claim"}, {"id": "claim_7", "text": "other/mixed: Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. — exhibit an approximately 20% increase in median survival.", "type": "claim"}, {"id": "claim_8", "text": "directionally favorable: Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis — Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.", "type": "claim"}, {"id": "claim_9", "text": "Candidate moderators are population or indication, endpoint, comparator, and study design/evidence type; these dimensions explain why the receipts should be read as divergent evidence fronts, not one pooled effect.", "type": "claim"}, {"id": "claim_10", "text": "The selected receipts group because each carries a fact-level extraction for mtor; they separate by context (animal model, human clinical/observational, and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_11", "text": "Source-literature boundary for mtor: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.", "type": "claim"}, {"id": "claim_12", "text": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/ndt/gfad258", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "International consensus on post-transplantation diabetes mellitus", "type": "source", "url": "https://doi.org/10.1093/ndt/gfad258", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1126/scitranslmed.3009892", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "mTOR inhibition improves immune function in the elderly", "type": "source", "url": "https://doi.org/10.1126/scitranslmed.3009892", "year": 2014}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1111/tri.12372", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.", "type": "source", "url": "https://doi.org/10.1111/tri.12372", "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1016/j.celrep.2013.07.030", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.", "type": "source", "url": "https://doi.org/10.1016/j.celrep.2013.07.030", "year": 2013}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1940-6207.capr-10-0055", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "type": "source", "url": "https://doi.org/10.1158/1940-6207.capr-10-0055", "year": 2010}], "publication_id": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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