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# Alpha memo: nicotinamide riboside exercise performance protocol mismatch
**One-sentence alpha:** Human and rat evidence together suggest nicotinamide riboside may help exercise outcomes in NAD(P)H-lower older adults yet trend the opposite in younger or pre-clinical contexts.
**Receipt 1:** *The NAD+ precursor nicotinamide riboside decreases exercise performance in rats* — chronic 300 mg/kg/day N…