Derivation Web

claim_000e98beef8444c8

# Research Synthesis: Rapamycin Effects — full paper

## Abstract

Evidence-honesty note: 22/36 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. 35/36 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefor…

source_ffe342feba1a44ef

# Research Synthesis: Rapamycin Effects — full paper

## Abstract

Evidence-honesty note: 22/36 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. 35/36 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefor…

source_217ac36f42174808

{"publication_id": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "traces": [{"candidate_sources": [{"doi": "10.1038/s41467-023-40734-8", "study": "Mandrioli 2023", "url": "https://doi.org/10.1038/s41467-023-40734-8"}, {"doi": "10.1007/s40520-022-02190-0", "study": "Lin 2022", "url": "https://doi.org/10.1007/s40520-022-02190-0"}, {"doi": "10.18632/aging.206235", "study": "Moel 2025", "url": "https://doi.…

source_34f313bbbe0347fd

{"content_hash": null, "edges": [{"from": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "to": "claim_1", "type": "contains_claim"}, {"from": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "to": "claim_2", "type": "contains_claim"}, {"from": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "to": "claim_3", "type": "contains_claim"}, {"from": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "to": "claim_4", "type": "contains_clai…

source_f075c87395af44c6

{"contradictions": ["The evidence profile indicates that while preclinical evidence for rapamycin's anti-aging potential is compelling, human data from controlled trials predominantly show null or inconsistent effects on clinical healthspan endpoints.", "Aging represents the single greatest risk factor for the leading causes of morbidity and mortality worldwide, including cardiovascular disease, c…

source_033caf6a3e234640

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Mandrioli 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Lin 2022,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Moel 2025,not extracted,not extracted,not extracted,not…

source_9064217071f04e2d

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "sources": [{"directness": "primary", "doi": "10.1038/s41467-023-40734-8", "risk_of_bias": "not appraised in public sidecar", "study": "Mandrioli 2023"}, {"directness": "review-level", "doi": "10.10…

source_3451acfc1e854d94

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}