Derivation Web

claim_06786ee2c99a4cd9

# Adjacent Evidence Brief: Alpha-klotho — full paper

## Abstract

This paper synthesizes evidence on Alpha-klotho across 52 accepted source papers and 2083 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 51 adjacent clinical sources, and 1 mechanistic or model-system source, with 60 cross-study disagreements across the …

source_bbf60709158f48ae

# Adjacent Evidence Brief: Alpha-klotho — full paper

## Abstract

This paper synthesizes evidence on Alpha-klotho across 52 accepted source papers and 2083 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 51 adjacent clinical sources, and 1 mechanistic or model-system source, with 60 cross-study disagreements across the …

source_93cd671d614444ff

{"publication_id": "e6926b4c-bd58-4b1d-8022-2a9ca3381c8f", "traces": [{"candidate_sources": [{"doi": "10.1007/s11255-025-04475-5", "study": "Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study", "url": "https://doi.org/10.1007/s11255-025-04475-5"}, {"doi": "10.1007/s13105-026-…

source_f99e5335e3334d1d

{"content_hash": "sha256:5e2bb4d489e0834a6417235132c0b816e4907e27d509a69a04d55be266201f13", "edges": [{"from": "e6926b4c-bd58-4b1d-8022-2a9ca3381c8f", "to": "claim_1", "type": "contains_claim"}, {"from": "e6926b4c-bd58-4b1d-8022-2a9ca3381c8f", "to": "claim_2", "type": "contains_claim"}, {"from": "e6926b4c-bd58-4b1d-8022-2a9ca3381c8f", "to": "claim_3", "type": "contains_claim"}, {"from": "e6926b4c-…

source_897900b9f9144f23

{"contradictions": ["The conclusion is that Alpha-klotho remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The geroscience hypothesis holds that targeting the biology of aging itself, rather than each chronic disease in isolation, may produce larger…

source_b36a457f65d24a72

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of acute, s…

source_6da67e5a398e4b0e

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "e6926b4c-bd58-4b1d-8022-2a9ca3381c8f", "sources": [{"directness": "primary", "doi": "10.1007/s11255-025-04475-5", "risk_of_bias": "not appraised in public sidecar", "study": "Association of serum Klotho and fibroblast growth factor-23 le…

source_d4bb6dc59cd24aa1

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}