Derivation Web

claim_0754422e078c4d8d

# Research Synthesis: Immune Age — full paper

## Abstract

This synthesis tests the thesis that evidence for Immune age is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Immune aging, characterized by chronic low-grade inflammation and diminished adaptive immune function, is increasingly recognized as…

source_5347a21127a64054

# Research Synthesis: Immune Age — full paper

## Abstract

This synthesis tests the thesis that evidence for Immune age is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Immune aging, characterized by chronic low-grade inflammation and diminished adaptive immune function, is increasingly recognized as…

source_6ea79f98e5f145ca

{"publication_id": "bd4ddec9-e10e-445f-bf0b-a5399dfae223", "traces": [{"candidate_sources": [{"doi": "10.1093/ecco-jcc/jjad049", "study": "Jongsma 2023", "url": "https://doi.org/10.1093/ecco-jcc/jjad049"}, {"doi": "10.1038/s41392-025-02252-5", "study": "Xie 2025", "url": "https://doi.org/10.1038/s41392-025-02252-5"}, {"doi": "10.3389/fimmu.2024.1413956", "study": "Wallen 2024", "url": "https://doi…

source_2daad45887b84262

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{"contradictions": ["Across the corpus, observational and cohort studies overwhelmingly dominate the literature; mechanistic preclinical work exists but direct randomized clinical trial evidence for interventions that modulate immune aging in humans remains sparse.", "The current evidence base for immune aging is therefore context-dependent and predominantly observational, with null-effect finding…

source_cb4d4380c70043a3

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Jongsma 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Xie 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Wallen 2024,not extracted,not extracted,not extracted,not extr…

source_2f904a5d566c4874

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "bd4ddec9-e10e-445f-bf0b-a5399dfae223", "sources": [{"directness": "primary", "doi": "10.1093/ecco-jcc/jjad049", "risk_of_bias": "not appraised in public sidecar", "study": "Jongsma 2023"}, {"directness": "primary", "doi": "10.1038/s41392…

source_0432f2a92ecb456c

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}