Derivation Web

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# Alpha memo: Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise

Hypothesis-level alpha signal; not clinical advice.
## Core signal
Two 2024 randomized trials in older adults define the same dose/regime but land on different ledger sides. 10.1002/ptr.8171 is a systematic review of randomized clinical trials in older adults reporti…

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# Alpha memo: Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise

Hypothesis-level alpha signal; not clinical advice.
## Core signal
Two 2024 randomized trials in older adults define the same dose/regime but land on different ledger sides. 10.1002/ptr.8171 is a systematic review of randomized clinical trials in older adults reporti…

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{"contradictions": ["Two 2024 randomized trials in older adults define the same dose/regime but land on different ledger sides. 10.1002/ptr.8171 is a systematic review of randomized clinical trials in older adults reporting that resveratrol combined with exercise improved exercise adaptation, muscle function, and physical performance/mobility. 10.1016/j.exger.2024.112479 is the embedded dose-rangi…

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study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects and safety of resveratrol supplementatio…

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{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "2371a466-c045-460d-a766-e242574bcc65", "sources": [{"directness": "primary", "doi": "10.1016/j.exger.2024.112479", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of resveratrol on changes in trimethylamine-N-oxide a…

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{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}