Derivation Web

claim_41226544390e4d8a

We conducted an AI-assisted structured evidence synthesis of 60 curated reference papers, applying a source-level audit trail that links every numeric claim to its source and flags cross-domain tensions across outcome classes (immune, longevity, cardiometabolic, contextual other).

Bibliometric output has matured (Jiang 2025) and clinical protocols are emerging (Lv 2023), yet the few human RCTs — …

source_300aab549f814513

We conducted an AI-assisted structured evidence synthesis of 60 curated reference papers, applying a source-level audit trail that links every numeric claim to its source and flags cross-domain tensions across outcome classes (immune, longevity, cardiometabolic, contextual other).

Bibliometric output has matured (Jiang 2025) and clinical protocols are emerging (Lv 2023), yet the few human RCTs — …

source_dc02f038d93347a6

{"publication_id": "073c460c-0262-46c7-88e4-bc96b9c25668", "traces": [{"candidate_sources": [{"doi": "10.3390/antiox11122413", "study": "Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial Cells: Implications in Alcohol-Mediated Vascular Diseases", "url": "https://doi.org/10.3390/antiox11122413"}, {"doi": "10.1007/s00345-024-05409-z", "study": "Radiotherapy and inflammaging: the inf…

source_18a7c09c306d44a2

{"content_hash": "sha256:ad23c969a1c16f57287abf3be5dd865cb2a51edb22b9fdbb2c5a29fcd30a4a71", "edges": [{"from": "073c460c-0262-46c7-88e4-bc96b9c25668", "to": "claim_1", "type": "contains_claim"}, {"from": "073c460c-0262-46c7-88e4-bc96b9c25668", "to": "claim_2", "type": "contains_claim"}, {"from": "073c460c-0262-46c7-88e4-bc96b9c25668", "to": "claim_3", "type": "contains_claim"}, {"from": "073c460c-…

source_bdb0e66944274d1b

{"contradictions": ["Across the corpus, the evidence supports inflammaging as a biologically grounded, biomarker-detectable phenomenon whose clinical translation remains incomplete: mechanistic plausibility coexists with mixed or sparse human RCT evidence, longevity-relevant cohorts (Ceolin 2025 vs Spray 2025) disagree in direction, and boundary conditions across populations, exposures, and supple…

source_8be5e0e763524b28

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial Cells: Implications in Alcohol-Mediated Vascular Diseases,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Radiotherapy and inflammaging: the influence of prostate cancer radiot…

source_e344c811aa96484b

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "073c460c-0262-46c7-88e4-bc96b9c25668", "sources": [{"directness": "primary", "doi": "10.3390/antiox11122413", "risk_of_bias": "not appraised in public sidecar", "study": "Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial…

source_e3fc479d0a5c4bd3

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}