Derivation Web

claim_4e27699df9ff4d3a

## Abstract

This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the source tier, direction, or outcome-class balance.

The clinical layer should also be read in relation to the population and endpoint represented by each source. A finding in one age group, disease context, or intervention sch…

source_e8edefd6e28a4c79

## Abstract

This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the source tier, direction, or outcome-class balance.

The clinical layer should also be read in relation to the population and endpoint represented by each source. A finding in one age group, disease context, or intervention sch…

source_2c20fb30ad38431c

{"publication_id": "9be40a10-b14d-4e4a-afff-f058a818c80b", "traces": [{"candidate_sources": [{"cited_as": "Wu 2025", "comparator": "not extracted", "directness": "direct", "doi": "10.1016/j.eclinm.2025.103633", "effect": "not extracted", "endpoint": "not extracted", "evidence_span": "In long-COVID, NR increased NAD+ within 5 weeks but did not significantly improve cognition, fatigue, sleep, or moo…

source_6b741101a06b40ff

{"content_hash": null, "edges": [{"from": "9be40a10-b14d-4e4a-afff-f058a818c80b", "to": "claim_1", "type": "contains_claim"}, {"from": "9be40a10-b14d-4e4a-afff-f058a818c80b", "to": "claim_2", "type": "contains_claim"}, {"from": "9be40a10-b14d-4e4a-afff-f058a818c80b", "to": "claim_3", "type": "contains_claim"}, {"from": "9be40a10-b14d-4e4a-afff-f058a818c80b", "to": "claim_4", "type": "contains_clai…

source_7b5a7a2eeb6a4f73

{"contradictions": ["Null findings have a specific role in this evidence model. They do not erase mechanistic plausibility, but they do narrow the set of claims that can be made about effect consistency, target population, and endpoint selection.", "For instance, while one trial reported a trend toward improved NYHA class in heart failure patients [Yu 2025] [bundle:4], other trials in different po…

source_67db9fd90b5f4e85

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,direct
NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Lo…

source_d9c33d4076b94ae4

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9be40a10-b14d-4e4a-afff-f058a818c80b", "sources": [{"directness": "direct", "doi": "10.1016/j.eclinm.2025.103633", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of nicotinamide riboside on NAD+ levels, cognition, a…

source_6cf474a1891343e5

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}