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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "accept"}

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# Alpha memo: Split response of nicotinamide riboside on exercise performance by age
**One-sentence alpha:** Nicotinamide riboside (NR) supplementation may shift from performance-impairing in young rats to performance-improving in older humans when baseline NAD(P)H status is low.
**Receipt 1:** "The NAD+ precursor nicotinamide riboside decreases exercise performance in rats" — In a 21-day gavage p…