Derivation Web

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{"decision": "revise", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "accept"}

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# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** Preclinical rat work suggested metformin plus swimming training may additively improve insulin sensitivity, whereas a human DARE re-analysis suggests metformin use may attenuate exercise-driven HbA1c and fitness gains — the same anchor splits by context.
**Receipt 1:** Effects Of Metformin Administration With …