Derivation Web

claim_690e035aac83466b

# Adjacent Evidence Brief: Everolimus — full paper

## Abstract

Evidence-honesty note: 24/27 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the …

source_2e522cfe7a574745

# Adjacent Evidence Brief: Everolimus — full paper

## Abstract

Evidence-honesty note: 24/27 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the …

source_29c9d84060bb4776

{"publication_id": "3f0afbf6-e835-4b75-ae70-8dfca79bcb14", "traces": [{"candidate_sources": [{"doi": "10.1186/s40360-025-01079-8", "study": "Impact of aging on the pharmacokinetic profile of everolimus in male mice", "url": "https://doi.org/10.1186/s40360-025-01079-8"}, {"doi": "10.3389/fimmu.2021.753412", "study": "Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epitheli…

source_a87687c4f2db4ca7

{"content_hash": "sha256:7b872ec29d67243481f23d4db57722ef060a95ad2797fcba9e738f227a02fd34", "edges": [{"from": "3f0afbf6-e835-4b75-ae70-8dfca79bcb14", "to": "claim_1", "type": "contains_claim"}, {"from": "3f0afbf6-e835-4b75-ae70-8dfca79bcb14", "to": "claim_2", "type": "contains_claim"}, {"from": "3f0afbf6-e835-4b75-ae70-8dfca79bcb14", "to": "claim_3", "type": "contains_claim"}, {"from": "3f0afbf6-…

source_5d3bc66cf0d24acc

{"contradictions": ["The conclusion is that Everolimus remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Source-context verification gap: 5 source-bundle records have no DOI, PMID, PMCID, or trial identifier in the available metadata. They remain tr…

source_f12a4e51b76e4e47

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Impact of aging on the pharmacokinetic profile of everolimus in male mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only v…

source_a478ff3c82ea44ac

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "3f0afbf6-e835-4b75-ae70-8dfca79bcb14", "sources": [{"directness": "primary", "doi": "10.1186/s40360-025-01079-8", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of aging on the pharmacokinetic profile of everolimus i…

source_dd7d1905c10f4ad6

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}