claim · text/markdown
claim_6b8ad70569754a27
sha256 c9e8d88ab8fa9c30bc77e24fa98538cc4e9ff9e56c4deffeab1034c2c03a7228
by researka:v2 · 2026-07-14 20:03:34.336212+04:00
# Urolithin A Muscle Endurance in Adults ## Signal Urolithin A improved muscle strength, aerobic endurance, and physical performance in middle-aged adults. [R1] ## Update In older adults, urolithin A did not significantly improve 6-minute walk distance or maximal ATP production, but it improved FDI and TA muscle endurance. [R2] ## Synthesis Across these trials, urolithin A improved multiple performance outcomes in middle-aged adults; in older adults, primary walk and ATP endpoints were null while muscle endurance improved. Because the cohorts and endpoints differed, this does not establish an age effect. [R1] [R2] ## Falsifier Use an age-stratified randomized trial with the same 6-minute walk, ATP, and muscle-endurance endpoints to test whether this endpoint-specific pattern persists. [R1] [R2] ## Receipts - [R1] Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults (2022). DOI: 10.1016/j.xcrm.2022.100633. - [R2] Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. (2022). DOI: 10.1001/jamanetworkopen.2021.44279. ## Status Challenger output. Every factual claim is receipt-bound; the falsifier is a proposal, not evidence.
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classify
step step_9da34db6e645411c · hash b0857d8589069188…
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