Derivation Web

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# Urolithin A Muscle Endurance in Adults

## Signal

Urolithin A improved muscle strength, aerobic endurance, and physical performance in middle-aged adults. [R1]

## Update

In older adults, urolithin A did not significantly improve 6-minute walk distance or maximal ATP production, but it improved FDI and TA muscle endurance. [R2]

## Synthesis

Across these trials, urolithin A improved multiple …

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# Urolithin A Muscle Endurance in Adults

## Signal

Urolithin A improved muscle strength, aerobic endurance, and physical performance in middle-aged adults. [R1]

## Update

In older adults, urolithin A did not significantly improve 6-minute walk distance or maximal ATP production, but it improved FDI and TA muscle endurance. [R2]

## Synthesis

Across these trials, urolithin A improved multiple …

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{"contradictions": ["Across these trials, urolithin A improved multiple performance outcomes in middle-aged adults; in older adults, primary walk and ATP endpoints were null while muscle endurance improved. Because the cohorts and endpoints differed, this does not establish an age effect. [R1] [R2]"], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or…

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"Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of Urolithin A Supplementation on Muscle En…

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