Derivation Web

claim_789460b431ab4a6d

# Hypothesis-Generating Brief: Spermidine supplementation — full paper
## Abstract

Evidence-honesty note: 35/42 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a …

source_b9e2434fc88045cc

# Hypothesis-Generating Brief: Spermidine supplementation — full paper
## Abstract

Evidence-honesty note: 35/42 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a …

source_bc572d2e263449b5

{"publication_id": "0326ee6c-57b7-4644-a7c4-9c81b0c5541c", "traces": [{"candidate_sources": [{"doi": "10.3390/cells10010095", "study": "Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile", "url": "https://doi.org/10.3390/cells10010095"}, {"doi": "10.1007/s12035-026-05763-6", "study": "Spermidine Attenuates Neuroimmune Dysfunction in Gulf War Illne…

source_81d393562e384ce8

{"content_hash": "sha256:9556ccfe3729e54ceb5a9e50ab90961712fe6e73b90c4129bd617e0e015833cb", "edges": [{"from": "0326ee6c-57b7-4644-a7c4-9c81b0c5541c", "to": "claim_1", "type": "contains_claim"}, {"from": "0326ee6c-57b7-4644-a7c4-9c81b0c5541c", "to": "claim_2", "type": "contains_claim"}, {"from": "0326ee6c-57b7-4644-a7c4-9c81b0c5541c", "to": "claim_3", "type": "contains_claim"}, {"from": "0326ee6c-…

source_51591c51aff041dc

{"contradictions": ["Positive study-level signals are summarized in the immune and inflammation outcome class; null signals are summarized in the contextual adjacent evidence, mechanism, dosing and pharmacokinetics, longevity, cardiometabolic, deficiency prevalence, muscle function, and skeletal, fracture, and bone outcome classes; negative signals are not the dominant direction in any outcome cla…

source_18683d268f014fc5

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine Attenuates Neuroimmune Dysfunction in Gulf War Illness via Modulation of the Gut- …

source_e83655c0fdac4070

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "0326ee6c-57b7-4644-a7c4-9c81b0c5541c", "sources": [{"directness": "primary", "doi": "10.3390/cells10010095", "risk_of_bias": "not appraised in public sidecar", "study": "Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response an…

source_6d221b2a00684b45

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}