Derivation Web

claim_9278650ba6ab48b5

# Research Synthesis: Epigenetic Clocks — full paper

## Abstract

Evidence-honesty note: 35/44 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used o…

source_04d73030f09743a5

# Research Synthesis: Epigenetic Clocks — full paper

## Abstract

Evidence-honesty note: 35/44 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used o…

source_5165139314914100

{"publication_id": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "traces": [{"candidate_sources": [{"doi": "10.1186/s13148-023-01480-2", "study": "Bozack 2023", "url": "https://doi.org/10.1186/s13148-023-01480-2"}, {"doi": "10.1007/s11357-024-01138-8", "study": "McGee 2024", "url": "https://doi.org/10.1007/s11357-024-01138-8"}, {"doi": "10.1186/s12958-025-01429-5", "study": "Marinello 2025", "url": "htt…

source_efc2e9717cdc42ac

{"content_hash": null, "edges": [{"from": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "to": "claim_1", "type": "contains_claim"}, {"from": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "to": "claim_2", "type": "contains_claim"}, {"from": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "to": "claim_3", "type": "contains_claim"}, {"from": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "to": "claim_4", "type": "contains_clai…

source_1eb8159ab12d4f20

{"contradictions": ["The conclusion is that epigenetic clocks should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "32 included sources were assigned to this outcome class. Directional coding: mixed=1, negative=1, null=28, unclear=2. …

source_1895cb8a7c8646cf

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Bozack 2023,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
McGee 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Marinello 2025,not extracted,not extracted,not extracted,not …

source_4aa47c9ce4de4eca

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9e9f3163-3f3b-4c1f-9790-a8b1400b8696", "sources": [{"directness": "primary", "doi": "10.1186/s13148-023-01480-2", "risk_of_bias": "not appraised in public sidecar", "study": "Bozack 2023"}, {"directness": "primary", "doi": "10.1007/s1135…

source_9a81a0d6119f42e1

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}