Derivation Web

claim_9c3a6102f79e4583

# Adjacent Evidence Brief: Senescence Effects — full paper
## Abstract

Evidence-honesty note: 50/54 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement th…

source_aadb4c2d4b5f4d12

# Adjacent Evidence Brief: Senescence Effects — full paper
## Abstract

Evidence-honesty note: 50/54 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement th…

source_42d12a7ed5d94530

{"publication_id": "51c45f7b-c31b-466a-8fb9-aae829be66ae", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.70114", "study": "Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches", "url": "https://doi.org/10.1111/acel.70114"…

source_96dbe8a82c034e91

{"content_hash": "sha256:fc6d7479529ed7e9015e25c750dd6e10ff93506c3fce868673b6d20513c50944", "edges": [{"from": "51c45f7b-c31b-466a-8fb9-aae829be66ae", "to": "claim_1", "type": "contains_claim"}, {"from": "51c45f7b-c31b-466a-8fb9-aae829be66ae", "to": "claim_2", "type": "contains_claim"}, {"from": "51c45f7b-c31b-466a-8fb9-aae829be66ae", "to": "claim_3", "type": "contains_claim"}, {"from": "51c45f7b-…

source_70f81fc9436045eb

{"contradictions": ["Positive study-level signals are not the dominant direction in any outcome class; null signals are summarized in the contextual adjacent evidence, immune and inflammation, cardiometabolic, immune and inflammation, muscle function, longevity, mortality and survival, and safety and comorbidity outcome classes; negative signals are not the dominant direction in any outcome class;…

source_36254b7214af450f

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised …

source_3bf1da8b2af24d93

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "51c45f7b-c31b-466a-8fb9-aae829be66ae", "sources": [{"directness": "primary", "doi": "10.1111/acel.70114", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent Supplementation With Fisetin Improves Physical Function a…

source_b1645db87f0b43fd

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}