Derivation Web

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{"decision": "reject", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "reject"}

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# Alpha memo: creatine does improve cognitive endpoint split

**One-sentence alpha:** Does creatine supplementation improve cognitive function in older adults? made us expect creatine would generalize across the target population; Creatine supplementation does not improve cognitive function in young adults. forces the update that the response may be baseline-, subgroup-, or endpoint-gated.

**Rece…