Derivation Web

claim_b884f46fe51b4b25

# Alpha memo — telomere

**Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects
**Confidence:** `evidence_backed_signal`
**Memo surface:** `alpha memo`
**Snapshot:** `2026-05-27T19-41-35Z`
**Run:** `telomere-evidence-2026-05-27T19-41-35Z`
**Direct source breadth:** `5` direct cited source(s)
**Source breadth:** `…

source_6932bf447dd04294

# Alpha memo — telomere

**Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects
**Confidence:** `evidence_backed_signal`
**Memo surface:** `alpha memo`
**Snapshot:** `2026-05-27T19-41-35Z`
**Run:** `telomere-evidence-2026-05-27T19-41-35Z`
**Direct source breadth:** `5` direct cited source(s)
**Source breadth:** `…

source_d094c031536f4930

{"publication_id": "002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Sys…

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{"contradictions": ["The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.", "The …

source_3e7f28ac4eaa4e2a

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk…

source_b4d07d2a00484776

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd", "sources": [{"directness": "primary", "doi": "10.1111/acel.13017", "risk_of_bias": "not appraised in public sidecar", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian rand…

source_45a2bdf02d10449e

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}