Derivation Web

claim_c12a39dbe8594dbd

# Hypothesis-Generating Brief: Low dose naltrexone inflammation — full paper

## Abstract

This paper synthesizes evidence on Low dose naltrexone inflammation across 39 accepted source papers and 1510 high-confidence extracted claims.

The evidence profile contains 3 direct clinical sources, 36 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, …

source_f9f31df69aed4789

# Hypothesis-Generating Brief: Low dose naltrexone inflammation — full paper

## Abstract

This paper synthesizes evidence on Low dose naltrexone inflammation across 39 accepted source papers and 1510 high-confidence extracted claims.

The evidence profile contains 3 direct clinical sources, 36 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, …

source_4051c2261f764803

{"publication_id": "3b9d2db0-4fb0-44d4-bab5-5c3b2794f100", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1016/j.bjane.2022.08.003", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia: a randomized, double-blin…

source_fce621564e944845

{"content_hash": "sha256:374b7bb9e5573f1e25e706d547f472c7bb3ff4ab07b3e1806942f02e90f5bb83", "edges": [{"from": "3b9d2db0-4fb0-44d4-bab5-5c3b2794f100", "to": "claim_1", "type": "contains_claim"}, {"from": "3b9d2db0-4fb0-44d4-bab5-5c3b2794f100", "to": "claim_2", "type": "contains_claim"}, {"from": "3b9d2db0-4fb0-44d4-bab5-5c3b2794f100", "to": "claim_3", "type": "contains_claim"}, {"from": "3b9d2db0-…

source_336460b7ac594281

{"contradictions": ["The conclusion is that Low dose naltrexone inflammation remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Aging is increasingly framed as a modifiable biological process rather than an immutable decline, and the question of whet…

source_770e44597c4e4548

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia: a randomized, double-blinded, parallel clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-dose naltrexone’s utility for non-cance…

source_916ff34e016642f4

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "3b9d2db0-4fb0-44d4-bab5-5c3b2794f100", "sources": [{"directness": "primary", "doi": "10.1016/j.bjane.2022.08.003", "risk_of_bias": "not appraised in public sidecar", "study": "Association of low-dose naltrexone and transcranial direct cu…

source_ca28a2f43ad24373

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}