Derivation Web

claim_c441eaed99e44c72

# Research Synthesis: Longevity Lifespan Effects — full paper

## Abstract

This paper synthesizes longevity lifespan effects as an aging-related intervention across 13 accepted source papers and 318 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 6 adjacent clinical sources, and 2 mechanistic or model-system sources, wi…

source_cf915b8ab0e94c96

# Research Synthesis: Longevity Lifespan Effects — full paper

## Abstract

This paper synthesizes longevity lifespan effects as an aging-related intervention across 13 accepted source papers and 318 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 6 adjacent clinical sources, and 2 mechanistic or model-system sources, wi…

source_4d4d2aadbd174eb4

{"publication_id": "9dac2b04-d8de-4675-a8de-11480ceb67ae", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.14392", "study": "The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis", "url": "https://doi.org/10.1111/acel.14392"}, {"doi": "10.3390/microorganisms14020314", "study": "Multi-Model Longevity Assays Reveal Lifespan- and Healthspan-Promoti…

source_50bd30de22a94ca5

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{"contradictions": ["The conclusion is that longevity lifespan effects should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The retained longevity lifespan effects corpus is reported by outcome class before any cross-domain interpret…

source_05736b6a0b9946a8

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Multi-Model Longevity Assays Reveal Lifespan- and Healthspan-Promoting Effects of Bacillus …

source_7b97e6ddb086412b

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9dac2b04-d8de-4675-a8de-11480ceb67ae", "sources": [{"directness": "review-level", "doi": "10.1111/acel.14392", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of cysteine on lifespan in three model organisms: A sy…

source_f67e4dc594dc4a26

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}