Derivation Web

claim_cc3ac2bc8c1944a1

# Research Synthesis: Nad Effects — full paper

## Abstract

Evidence-honesty note: 15/29 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the sour…

source_f223fdd7dcc14159

# Research Synthesis: Nad Effects — full paper

## Abstract

Evidence-honesty note: 15/29 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the sour…

source_8f7d91959f024162

{"publication_id": "ca403171-b282-4695-8058-9dd6bfe3754b", "traces": [{"candidate_sources": [{"doi": "10.1038/s41598-023-29787-3", "study": "Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial", "url": "https://doi.org/10.1038/s41598-023-29787-3"}, {"doi": "10.1093/jn/n…

source_3f01bf00f4f14c32

{"content_hash": "sha256:5789507538ddd4b0277f831d115f057d9712437000037ce2c7c34abf8599529e", "edges": [{"from": "ca403171-b282-4695-8058-9dd6bfe3754b", "to": "claim_1", "type": "contains_claim"}, {"from": "ca403171-b282-4695-8058-9dd6bfe3754b", "to": "claim_2", "type": "contains_claim"}, {"from": "ca403171-b282-4695-8058-9dd6bfe3754b", "to": "claim_3", "type": "contains_claim"}, {"from": "ca403171-…

source_5b649ae2c1b140a1

{"contradictions": ["The conclusion is that nad effects should be treated as a bounded geroscience hypothesis: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Evidence for this outcome class is represented in the structured results table, but the retained narrative paragraphs wer…

source_c3919a3e2e8d49cc

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD + -Pre…

source_d9083ee067b640ac

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "ca403171-b282-4695-8058-9dd6bfe3754b", "sources": [{"directness": "primary", "doi": "10.1038/s41598-023-29787-3", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide adenine dinucleotide metabolism and arterial stif…

source_8a336e6d26784e48

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}