Derivation Web

claim_cda68446a4464861

# Hypothesis-Generating Brief: GLP-1 longevity — full paper
## Abstract

Evidence-honesty note: 27/52 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement t…

source_0ad95ddd5d154ffd

# Hypothesis-Generating Brief: GLP-1 longevity — full paper
## Abstract

Evidence-honesty note: 27/52 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement t…

source_3def4957dd22487e

{"publication_id": "2b3d1eb0-8efe-4468-b234-8a534f83b06b", "traces": [{"candidate_sources": [{"doi": "10.1155/jobe/3442754", "study": "Weight Loss Efficacy of Tirzepatide Compared to Placebo or GLP-1 Receptor Agonists in Adults With Obesity or Overweight: A Meta-Analysis of Randomized Controlled Trials With ≥ 20 Weeks Treatment Duration", "url": "https://doi.org/10.1155/jobe/3442754"}, {"doi": "10…

source_3447b6efceaf4ddd

{"content_hash": "sha256:99fa6d16c2604147fe0cda2c4928fd050970836632d0c9453339748a7a3b795d", "edges": [{"from": "2b3d1eb0-8efe-4468-b234-8a534f83b06b", "to": "claim_1", "type": "contains_claim"}, {"from": "2b3d1eb0-8efe-4468-b234-8a534f83b06b", "to": "claim_2", "type": "contains_claim"}, {"from": "2b3d1eb0-8efe-4468-b234-8a534f83b06b", "to": "claim_3", "type": "contains_claim"}, {"from": "2b3d1eb0-…

source_291acc4140bf4395

{"contradictions": ["The corpus contains 2 direct clinical sources, 50 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence. That distribution makes the synthesis appropriate for evaluating convergence, boundary conditions, and trial-design implications, while requiring caution around any conclusion that would exceed the direct human evidence.", "T…

source_c35f23fb5e464981

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Weight Loss Efficacy of Tirzepatide Compared to Placebo or GLP-1 Receptor Agonists in Adults With Obesity or Overweight: A Meta-Analysis of Randomized Controlled Trials With ≥ 20 Weeks Treatment Duration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,…

source_0107da46c7c04f8a

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "2b3d1eb0-8efe-4468-b234-8a534f83b06b", "sources": [{"directness": "review-level", "doi": "10.1155/jobe/3442754", "risk_of_bias": "not appraised in public sidecar", "study": "Weight Loss Efficacy of Tirzepatide Compared to Placebo or GLP-…

source_33b55b1f1d1544d2

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}