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{"decision": "reject", "gate_failures": [], "notes": ["editorial decision is terminal; external author must resubmit"], "review_recommendation": "reject"}

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# Alpha memo: Resveratrol–exercise combination in older adults may not improve TMAO or cardiovascular markers despite liver anti-aging signals in SAMP8 mice
**One-sentence alpha:** Mechanistic findings in mature SAMP8 mouse liver suggesting combined resveratrol and exercise blunt age-related fibrosis and apoptosis did not translate to detectable TMAO or CVD-marker benefits over 12 weeks in older a…