Derivation Web

claim_d98ac5bce0ae4d91

# Hypothesis-Generating Brief: ABT-263 — full paper

## Abstract

This paper synthesizes evidence on ABT-263 across 33 accepted source papers and 1290 high-confidence extracted claims.

The evidence profile contains 1 direct clinical source, 26 adjacent clinical sources, and 6 mechanistic or model-system sources, with 46 cross-study disagreements across the evidence base.

Positive study-level sig…

source_a3a0a7c9c56643ae

# Hypothesis-Generating Brief: ABT-263 — full paper

## Abstract

This paper synthesizes evidence on ABT-263 across 33 accepted source papers and 1290 high-confidence extracted claims.

The evidence profile contains 1 direct clinical source, 26 adjacent clinical sources, and 6 mechanistic or model-system sources, with 46 cross-study disagreements across the evidence base.

Positive study-level sig…

source_97ed2e8f13454cfb

{"publication_id": "825b123b-8868-470c-9e7e-9196adde37c5", "traces": [{"candidate_sources": [{"doi": "10.1016/j.ebiom.2023.104481", "study": "Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability", "url": "https://doi.org/10.1016/j.ebiom.2023.104481"}, {"doi"…

source_3fc7f620839e4055

{"content_hash": "sha256:361af0f178a616d030624ca7fc8fd2bb47f9c638155b0edecd128406742ab0a3", "edges": [{"from": "825b123b-8868-470c-9e7e-9196adde37c5", "to": "claim_1", "type": "contains_claim"}, {"from": "825b123b-8868-470c-9e7e-9196adde37c5", "to": "claim_2", "type": "contains_claim"}, {"from": "825b123b-8868-470c-9e7e-9196adde37c5", "to": "claim_3", "type": "contains_claim"}, {"from": "825b123b-…

source_3a63041df12a4af8

{"contradictions": ["The conclusion is that ABT-263 remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Evidence for this outcome class is represented in the structured results table, but the retained narrative paragraphs were more strongly assigne…

source_54ac9df12ac5404f

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary…

source_7e7aaec71bd54e73

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "825b123b-8868-470c-9e7e-9196adde37c5", "sources": [{"directness": "primary", "doi": "10.1016/j.ebiom.2023.104481", "risk_of_bias": "not appraised in public sidecar", "study": "Senolytics dasatinib and quercetin in idiopathic pulmonary fi…

source_fe32b81b76404fac

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}