Derivation Web

claim_dfb61cdfc5da412e

# Research Synthesis: Alpha-ketoglutarate — full paper

## Abstract

Evidence-honesty note: 46/53 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that …

source_46b4509576424530

# Research Synthesis: Alpha-ketoglutarate — full paper

## Abstract

Evidence-honesty note: 46/53 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that …

source_7984f85215bb4c85

{"publication_id": "eff2808f-cded-4bcd-b7a5-59a823b84f7b", "traces": [{"candidate_sources": [{"doi": "10.3390/cimb45080410", "study": "Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF", "url": "https://doi.org/10.3390/cimb45080410"}, {"doi": "10.3390/ijms23169034", "study": "Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectiv…

source_8c24d557c6f64dc5

{"content_hash": "sha256:259fc5c5201345c13b9fef14f0b856e34339657122e85c238bac7b91bb4b1d3d", "edges": [{"from": "eff2808f-cded-4bcd-b7a5-59a823b84f7b", "to": "claim_1", "type": "contains_claim"}, {"from": "eff2808f-cded-4bcd-b7a5-59a823b84f7b", "to": "claim_2", "type": "contains_claim"}, {"from": "eff2808f-cded-4bcd-b7a5-59a823b84f7b", "to": "claim_3", "type": "contains_claim"}, {"from": "eff2808f-…

source_eb0ead3c41db4ae1

{"contradictions": ["The conclusion is that Alpha-ketoglutarate remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "4 included sources were assigned to this outcome class. Directional coding: mixed=1, null=3. Directness coding: mechanistic=4.", "Evide…

source_d0ec4f4243c84546

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia…

source_1197d7e17eb642a1

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "eff2808f-cded-4bcd-b7a5-59a823b84f7b", "sources": [{"directness": "primary", "doi": "10.3390/cimb45080410", "risk_of_bias": "not appraised in public sidecar", "study": "Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying A…

source_5d1698b7319a4397

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}