Derivation Web

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# Urolithin A Endurance Efficacy

## Signal

Urolithin A improves muscle strength, aerobic endurance, and physical performance in middle-aged adults. [R1]

## Update

Urolithin A failed to significantly improve 6-minute walk distance and maximal ATP production in adults aged 65 to 90. [R2]

## Synthesis

Efficacy varies by age cohort, with benefits observed in middle-aged adults but absent for pri…