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# Alpha memo: nicotinamide riboside exercise performance context boundary
**One-sentence alpha:** Nicotinamide riboside supplementation suggests context-dependent exercise effects that may split by age/baseline status rather than acting as a uniform ergogenic.
**Receipt 1:** The NAD+ precursor nicotinamide riboside decreases exercise performance in rats (2016) — chronic 21-day NR at 300 mg/kg/day …