Derivation Web

claim_0115fc4cf04d4819

**Selected angle:** `source`

## One-sentence thesis

Across 4 independently cited sources, the evidence converges on one bounded claim: caloric restriction modulates metabolic and endocrine biomarkers (IGF-1, FGF-21, glucose tolerance) in rodents. Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.

**Interpretation note:** This is a hypothesis…

source_b8aa585bfa044a64

**Selected angle:** `source`

## One-sentence thesis

Across 4 independently cited sources, the evidence converges on one bounded claim: caloric restriction modulates metabolic and endocrine biomarkers (IGF-1, FGF-21, glucose tolerance) in rodents. Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.


**Interpretation note:** This is a hypothesi…

source_173298c5ed7c4572

{"publication_id": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "traces": [{"candidate_sources": [{"doi": "10.7554/elife.88080", "study": "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent", "url": "https://pubmed.ncbi.nlm.nih.gov/37096321/"}, {"doi": "10.1111/acel.12203", "study": "Altered proteome turnover and remodeling by short‐term caloric restric…

source_190a2fa458954bc3

{"content_hash": null, "edges": [{"from": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "to": "claim_1", "type": "contains_claim"}, {"from": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "to": "claim_2", "type": "contains_claim"}, {"from": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "to": "claim_3", "type": "contains_claim"}, {"from": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "to": "claim_4", "type": "contains_clai…

source_d1ee546f7fd5453a

{"contradictions": ["_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty f…

source_71b9cca49fa541a0

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuve…

source_fa0f762712514e45

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9071bd4f-9969-4a7f-85ee-ae7c64682a16", "sources": [{"directness": "primary", "doi": "10.7554/elife.88080", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of caloric restriction on adipose tissue and metabolic he…

source_32c51761307c4812

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}