Derivation Web

claim_13ee8763310d4f4a

# Research Synthesis: Rapamycin Biomarker Effects — full paper

## Abstract

Evidence-honesty note: 20/30 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a stateme…

source_e00ba2e580e24c51

# Research Synthesis: Rapamycin Biomarker Effects — full paper

## Abstract

Evidence-honesty note: 20/30 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a stateme…

source_6000a038497745b5

{"publication_id": "b3041d87-87dd-46e9-a8ea-5a13c317c885", "traces": [{"candidate_sources": [{"doi": "10.1002/advs.202507210", "study": "Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models", "url": "https://doi.org/10.1002/advs.202507210"}, {"doi": "10.18632/aging.206235", "study": "Influence of rapamycin on safety and he…

source_4d1be35711a14eb9

{"content_hash": "sha256:d15f190529a22a26bc911cfce84fc3b8ab42e104cb948a5b1c7c69d5803ef1fd", "edges": [{"from": "b3041d87-87dd-46e9-a8ea-5a13c317c885", "to": "claim_1", "type": "contains_claim"}, {"from": "b3041d87-87dd-46e9-a8ea-5a13c317c885", "to": "claim_2", "type": "contains_claim"}, {"from": "b3041d87-87dd-46e9-a8ea-5a13c317c885", "to": "claim_3", "type": "contains_claim"}, {"from": "b3041d87-…

source_004dd594ee0849d5

{"contradictions": ["Across outcome classes, cross-study disagreements were identified, with null findings dominating contextual and safety outcomes while context-specific signals concentrated in preclinical longevity and immune biomarker domains.", "The current evidence supports mechanistic plausibility for rapamycin's geroprotective effects but falls short of establishing clinical biomarker effi…

source_0e61f647bfe54c50

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Influence of rapamycin on safety and healthspan metrics after one …

source_300af31c5ed14e91

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "b3041d87-87dd-46e9-a8ea-5a13c317c885", "sources": [{"directness": "primary", "doi": "10.1002/advs.202507210", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunc…

source_668690069b9a4db3

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}