Derivation Web

claim_2825c53d05d3469f

# Source literature boundary memo

## Research question

Across retrieved source-level receipts for metformin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature selector kept metformin because the candidate bundle met the public source rule: 5 citable papers, 5 distinct fact-backed …

source_87a2bd6e77aa49e5

# Source literature boundary memo

## Research question

Across retrieved source-level receipts for metformin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature selector kept metformin because the candidate bundle met the public source rule: 5 citable papers, 5 distinct fact-backed …

source_2b1f5e3ae58d48f9

{"publication_id": "f585d82f-ef44-4c56-be90-980cfd58978a", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1111/1440-1681.12265", "effect": "not extracted", "endpoint": "Wechsler Memory Scale-Revised cognitive performance", "population": "Depressed patients with type 2 diabetes mellitus", "source_id": "source_1", "study": "Metformin may produce antidepressant effects through…

source_6c6d8bc9d53649c9

{"content_hash": null, "edges": [{"from": "f585d82f-ef44-4c56-be90-980cfd58978a", "to": "claim_1", "type": "contains_claim"}, {"from": "f585d82f-ef44-4c56-be90-980cfd58978a", "to": "claim_2", "type": "contains_claim"}, {"from": "f585d82f-ef44-4c56-be90-980cfd58978a", "to": "claim_3", "type": "contains_claim"}, {"from": "f585d82f-ef44-4c56-be90-980cfd58978a", "to": "claim_4", "type": "contains_clai…

source_c1fba8d8a697443b

{"contradictions": ["This receipt-backed scoping note has one bounded signal: metformin shows endpoint-specific favorable signals with context limits across this 5-source primary/review bundle (2010-2022). Evidence role grouping: direction-bearing receipts: 4; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 1 excluded from effect support. The source facts cover 5 pop…

source_2e6b9a0a579d40b0

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus,Depressed patients with type 2 diabetes mellitus,Metformin 24-week chronic treatment,not extracted,Wechsler Memory Scale-Revised cognitive performance,not extracted,not ap…

source_265afa55f95f4392

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f585d82f-ef44-4c56-be90-980cfd58978a", "sources": [{"directness": "primary", "doi": "10.1111/1440-1681.12265", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin may produce antidepressant effects through improvement …

source_a030810be88a4c70

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}