Derivation Web

claim_28961f18aa5e488a

# Adjacent Evidence Brief: Young plasma — full paper
## Abstract

This synthesis tests the thesis that evidence for Young plasma is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Evidence-honesty note: 13/17 retained sources are coded as null or no extracted directional signal; this corpus is non-suppo…

source_f548295c7517406e

# Adjacent Evidence Brief: Young plasma — full paper
## Abstract

This synthesis tests the thesis that evidence for Young plasma is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Evidence-honesty note: 13/17 retained sources are coded as null or no extracted directional signal; this corpus is non-suppo…

source_2d9bee4ea7744d41

{"publication_id": "f2d5e407-7f5f-4de0-8775-b05423c0edb8", "traces": [{"candidate_sources": [{"doi": "10.1038/s43587-024-00612-4", "study": "Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism", "url": "https://doi.org/10.1038/s43587-024-00612-4"}, {"doi": "10.3390/brainsci14070656", "study": "Effect of Young Plasma Th…

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{"content_hash": "sha256:80a51d3249f12f18f1015512d81324cc371fc893e69e9881d5863ce3be41bd6f", "edges": [{"from": "f2d5e407-7f5f-4de0-8775-b05423c0edb8", "to": "claim_1", "type": "contains_claim"}, {"from": "f2d5e407-7f5f-4de0-8775-b05423c0edb8", "to": "claim_2", "type": "contains_claim"}, {"from": "f2d5e407-7f5f-4de0-8775-b05423c0edb8", "to": "claim_3", "type": "contains_claim"}, {"from": "f2d5e407-…

source_6d6a1ffe5ef74061

{"contradictions": ["The conclusion is that Young plasma should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "| Other/unclear species n=6 | unclear or mixed design | 6 | Ceylani 2023: The rejuvenating influence of young plasma on age…

source_2c12e7f03d2f460b

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of Young Plasma Therapy on Cognition, Oxidative Stress,…

source_fa7e109cc49e47b2

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f2d5e407-7f5f-4de0-8775-b05423c0edb8", "sources": [{"directness": "primary", "doi": "10.1038/s43587-024-00612-4", "risk_of_bias": "not appraised in public sidecar", "study": "Small extracellular vesicles from young plasma reverse age-rel…

source_6980cb9bcaa54f31

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}