Derivation Web

claim_32ab8f7b69994594

# Research Synthesis: Vitamin D Supplementation Effects — full paper

## Abstract

Evidence-honesty note: 58/62 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.

Vitamin D supplementation is among the most widely prescribed interventions worldwide, yet…

source_0d0003ec70f14e68

# Research Synthesis: Vitamin D Supplementation Effects — full paper

## Abstract

Evidence-honesty note: 58/62 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.

Vitamin D supplementation is among the most widely prescribed interventions worldwide, yet…

source_c53f6b2f31a54ea8

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{"contradictions": ["Overall, the evidence supports that vitamin D supplementation reliably raises serum 25(OH)D and may offer modest mortality or inflammatory benefits in specific clinical contexts, but effects on cardiometabolic hard endpoints, musculoskeletal function, and frailty prevention remain insufficiently suggested by current human RCTs.", "Aging populations worldwide face a growing bur…

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study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Vitamin D supplementation and exercise for improving physical function, body composition and metabolic health in overweight or obese older adults with vitamin D deficiency: a pilot randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,no…

source_536df942ca054354

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "c1cbca14-3224-46cc-bd1f-bc4a92a69d25", "sources": [{"directness": "primary", "doi": "10.1007/s00394-022-03038-z", "risk_of_bias": "not appraised in public sidecar", "study": "Vitamin D supplementation and exercise for improving physical …

source_b1524e3ec34746ac

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "revise"}