Derivation Web

claim_522c1b0b74f64f9a

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for epigenetic_clocks, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected epigenetic_clocks because the domain snapshot exposed enough fact-backed, topic-overlapping papers…

source_7cbf2afd35544cae

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for epigenetic_clocks, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected epigenetic_clocks because the domain snapshot exposed enough fact-backed, topic-overlapping papers…

source_4a850d7aaf5f43b8

{"publication_id": "89420d0f-7abc-427a-abec-7fc47b625264", "traces": [{"candidate_sources": [{"doi": "10.1002/ece3.72424", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).", "url": "https://doi.org/10.1002/ece3.72424"}, {"doi": "10.1111/acel.14451", "study": "Cross‐tissue comparison of epigenetic aging clocks in humans", "url": "h…

source_83b696e27fd14d7d

{"content_hash": null, "edges": [{"from": "89420d0f-7abc-427a-abec-7fc47b625264", "to": "claim_1", "type": "contains_claim"}, {"from": "89420d0f-7abc-427a-abec-7fc47b625264", "to": "claim_2", "type": "contains_claim"}, {"from": "89420d0f-7abc-427a-abec-7fc47b625264", "to": "claim_3", "type": "contains_claim"}, {"from": "89420d0f-7abc-427a-abec-7fc47b625264", "to": "claim_4", "type": "contains_clai…

source_fd1a438b59294adc

{"contradictions": ["This receipt-backed scoping note has one bounded signal: epigenetic_clocks shows context-dependent, not uniformly convergent associations across this 5-source primary bundle (2022-2025). Grouped by direction, other/mixed: 5 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverg…

source_f60fd201147e4214

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Delphinus delphis).,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Cross‐tissue comparison of epigenetic aging clocks in humans,not extracted,not extracted…

source_a7c1e26b10f84f08

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "89420d0f-7abc-427a-abec-7fc47b625264", "sources": [{"directness": "primary", "doi": "10.1002/ece3.72424", "risk_of_bias": "not appraised in public sidecar", "study": "Dental Ageing Offers New Insights Into the First Epigenetic Clock for …

source_a593dae0d5584e57

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}