Derivation Web

claim_52821b0335d9418b

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for fisetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected fisetin because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback requi…

source_2e9d811084584417

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for fisetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected fisetin because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback requi…

source_87d3cfb97f964302

{"publication_id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihyd…

source_1e343cd0ea064af5

{"content_hash": null, "edges": [{"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_1", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_2", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_3", "type": "contains_claim"}, {"from": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "to": "claim_4", "type": "contains_clai…

source_207d7d973e2a4805

{"contradictions": ["This receipt-backed scoping note has one bounded signal: fisetin shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2010-2023). Grouped by direction: directionally favorable: 3 receipt(s) | other/mixed: 2 receipt(s). The source facts cover 5 population context(s) and 4 intervention/exposure context(s), so this is a scoping signal…

source_759af68e94de4ca3

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fiset…

source_7bc967db30354f55

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "sources": [{"directness": "primary", "doi": "10.1111/acel.14060", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent supplementation with fisetin improves arterial function i…

source_59344cb82dae4453

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}