Derivation Web

claim_5a0569911adc4f71

# Alpha memo: nicotinamide riboside exercise performance
**One-sentence alpha:** Nicotinamide riboside supplementation may improve exercise performance only when recipients are NAD(P)H-deficient, with the same molecule impairing performance in young/replete animals.
**Receipt 1:** "The NAD+ precursor nicotinamide riboside decreases exercise performance in rats" (2016) — Chronic 21-day NR administr…

source_2a742c1c2ec14518

# Alpha memo: nicotinamide riboside exercise performance
**One-sentence alpha:** Nicotinamide riboside supplementation may improve exercise performance only when recipients are NAD(P)H-deficient, with the same molecule impairing performance in young/replete animals.
**Receipt 1:** "The NAD+ precursor nicotinamide riboside decreases exercise performance in rats" (2016) — Chronic 21-day NR administr…

source_69e353b7d4af4dbd

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source_e9f6d6ee8a084d6c

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{"contradictions": ["Receipt 2:** \"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study\" (2020) — Acute NR supplementation in older men (who exhibited lower erythrocyte NAD(P)H and higher urine F₂-isoprostanes at baseline) increased NAD(P)H levels, decreased oxidative stress, and improved VO₂-related p…

source_7ed7fc9b8ee84555

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The NAD + precursor nicotinamide riboside decreases exercise performance in rats,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals…

source_730365fde57747c4

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "06888b97-d174-4ea3-8963-a9e4112d22e8", "sources": [{"directness": "primary", "doi": "10.1186/s12970-016-0143-x", "risk_of_bias": "not appraised in public sidecar", "study": "The NAD + precursor nicotinamide riboside decreases exercise pe…

source_797499bc56eb4b7b

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}