Derivation Web

claim_65908feb7f7e405f

# Adjacent Evidence Brief: Sirtuin Biomarker Effects — full paper
## Abstract

Evidence-honesty note: 11/14 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a state…

source_c8f2f0d42e0b4c61

# Adjacent Evidence Brief: Sirtuin Biomarker Effects — full paper
## Abstract

Evidence-honesty note: 11/14 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a state…

source_bb82cd6996a34fb9

{"publication_id": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6", "traces": [{"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health…

source_01b9c9d8a31c4705

{"content_hash": "sha256:8a666fad4c2fc8a8f0c67fdc51e2014828c1621598064adbdac3f5e8562f17e6", "edges": [{"from": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6", "to": "claim_1", "type": "contains_claim"}, {"from": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6", "to": "claim_2", "type": "contains_claim"}, {"from": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6", "to": "claim_3", "type": "contains_claim"}, {"from": "1c0cf558-…

source_fd60548422074c39

{"contradictions": ["Positive study-level signals are summarized in the immune and inflammation outcome class; null signals are summarized in the contextual adjacent evidence, deficiency prevalence, and immune and inflammation outcome classes; negative signals are not the dominant direction in any outcome class; mixed or heterogeneous signals are summarized in the cardiometabolic outcome class. Th…

source_4f63b4326dd04409

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The sirtuin family in health and disease,not extracted,not extracted…

source_5fe4de6916cf4766

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6", "sources": [{"directness": "primary", "doi": "10.1186/s12933-025-03013-y", "risk_of_bias": "not appraised in public sidecar", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of e…

source_3156819a504f461d

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}