Derivation Web

claim_666762bbb8c9404e

# Source literature boundary memo

## Research question

Across retrieved source-level receipts for metformin_longevity, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected metformin_longevity because the domain snapshot exposed enough source-backed, topic-overlappin…

source_e932e0e772cc4cc7

# Source literature boundary memo

## Research question

Across retrieved source-level receipts for metformin_longevity, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected metformin_longevity because the domain snapshot exposed enough source-backed, topic-overlappin…

source_4e7bd2ebfc4a4528

{"publication_id": "62430fb3-2826-496e-a45c-494e9acdb5ba", "traces": [{"candidate_sources": [{"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": "https://doi.org/10.3389/fmed.2021.640785"}, {"doi": "10.1172/jci.insight.133247", "study": "Phase II clinical t…

source_969215c285a244f6

{"content_hash": null, "edges": [{"from": "62430fb3-2826-496e-a45c-494e9acdb5ba", "to": "claim_1", "type": "contains_claim"}, {"from": "62430fb3-2826-496e-a45c-494e9acdb5ba", "to": "claim_2", "type": "contains_claim"}, {"from": "62430fb3-2826-496e-a45c-494e9acdb5ba", "to": "claim_3", "type": "contains_claim"}, {"from": "62430fb3-2826-496e-a45c-494e9acdb5ba", "to": "claim_4", "type": "contains_clai…

source_cf11d45d450c4a97

{"contradictions": ["null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable."], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty field…

source_a997c274fd294759

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Phase II clinical trial of metformin as a cancer stem c…

source_50f5db3e713c4992

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "62430fb3-2826-496e-a45c-494e9acdb5ba", "sources": [{"directness": "primary", "doi": "10.3389/fmed.2021.640785", "risk_of_bias": "not appraised in public sidecar", "study": "Association Between Preadmission Metformin Use and Outcomes in I…

source_ed2e7cf5bc0d4719

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}