Derivation Web

claim_66d9397c47604f0e

# Research Synthesis: Epigenome editing longevity — full paper

## Abstract

Evidence-honesty note: 16/16 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a stateme…

source_9b6e24cdbb9e4ced

# Research Synthesis: Epigenome editing longevity — full paper

## Abstract

Evidence-honesty note: 16/16 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a stateme…

source_566a3e0199dd439c

{"publication_id": "f7b01234-38e2-4b03-b28b-707000e0635b", "traces": [{"candidate_sources": [{"doi": "10.1093/nar/gkac123", "study": "Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing", "url": "https://doi.org/10.1093/nar/gkac123"}, {"doi": "10.1038/s41467-020-14362-5", "study": "Interrogation of enhancer function by enhancer-targe…

source_29192f92720140c3

{"content_hash": "sha256:9b8e368961572bb9ca5e0648449b76ee3d70a582ae943e550f935eba56748af2", "edges": [{"from": "f7b01234-38e2-4b03-b28b-707000e0635b", "to": "claim_1", "type": "contains_claim"}, {"from": "f7b01234-38e2-4b03-b28b-707000e0635b", "to": "claim_2", "type": "contains_claim"}, {"from": "f7b01234-38e2-4b03-b28b-707000e0635b", "to": "claim_3", "type": "contains_claim"}, {"from": "f7b01234-…

source_f4cad21a4050418c

{"contradictions": ["The conclusion is that Epigenome editing longevity should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The retained Epigenome editing longevity corpus is reported by outcome class before any cross-domain interpr…

source_dcdd9aa28ea84750

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic edi…

source_5571ebf361d54894

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "f7b01234-38e2-4b03-b28b-707000e0635b", "sources": [{"directness": "primary", "doi": "10.1093/nar/gkac123", "risk_of_bias": "not appraised in public sidecar", "study": "Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and E…

source_2ab4296eecd14f7b

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}