Derivation Web

claim_6dcc69f764d74a0b

# Research Synthesis: Nad Biomarker Effects — full paper

## Abstract

Evidence-honesty note: 9/16 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that…

source_9742d044c28740a8

# Research Synthesis: Nad Biomarker Effects — full paper

## Abstract

Evidence-honesty note: 9/16 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that…

source_d2785eec9a4f4151

{"publication_id": "43509a3d-2c33-48fb-9e4f-c3802c27d437", "traces": [{"candidate_sources": [{"doi": "10.1038/s41598-025-95735-y", "study": "Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models", "url": "https://doi.org/10.1038/s41598-025-95735-y"}, {"doi": "10.3389/fcvm.2021.712478", "stu…

source_4354462223bf4255

{"content_hash": "sha256:70e670629d8c83d6969b4857a2a148fe55b84ba20f517d1394f9a3319a28ae79", "edges": [{"from": "43509a3d-2c33-48fb-9e4f-c3802c27d437", "to": "claim_1", "type": "contains_claim"}, {"from": "43509a3d-2c33-48fb-9e4f-c3802c27d437", "to": "claim_2", "type": "contains_claim"}, {"from": "43509a3d-2c33-48fb-9e4f-c3802c27d437", "to": "claim_3", "type": "contains_claim"}, {"from": "43509a3d-…

source_6ff51127ed90458a

{"contradictions": ["The conclusion is that nad biomarker effects should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Population aging is accelerating worldwide, yet the biology of aging itself has only recently been proposed as a t…

source_8eeffff2145c4fea

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Cardioprotecive Properties…

source_5c852f178d7e4caa

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "43509a3d-2c33-48fb-9e4f-c3802c27d437", "sources": [{"directness": "review-level", "doi": "10.1038/s41598-025-95735-y", "risk_of_bias": "not appraised in public sidecar", "study": "Meta-analysis of niacin and NAD metabolite treatment in i…

source_79c8beba0100442b

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}