Derivation Web

claim_7749012087cd4e2a

# Hypothesis-Generating Brief: NAD+ Metabolism Effects — full paper

## Abstract

Evidence-honesty note: 13/19 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a st…

source_3b21d48645a04bfb

# Hypothesis-Generating Brief: NAD+ Metabolism Effects — full paper

## Abstract

Evidence-honesty note: 13/19 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a st…

source_fb30337820774c24

{"publication_id": "529fbc6c-66ad-49b5-910a-f2b076cb190c", "traces": [{"candidate_sources": [{"doi": "10.1016/j.isci.2026.114764", "study": "The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation", "url": "https://doi.org/10.1016/j.isci.2026.114764"}, {"doi": "10.1038/s41598-023-29787-3", "study": "Nicotinamide adenine dinucleotide metabolis…

source_19d6be67e5254bca

{"content_hash": "sha256:dc5c405a0ed1a819e11866be41603b009b133a97fd858cd4fb4ccb37f3acdd35", "edges": [{"from": "529fbc6c-66ad-49b5-910a-f2b076cb190c", "to": "claim_1", "type": "contains_claim"}, {"from": "529fbc6c-66ad-49b5-910a-f2b076cb190c", "to": "claim_2", "type": "contains_claim"}, {"from": "529fbc6c-66ad-49b5-910a-f2b076cb190c", "to": "claim_3", "type": "contains_claim"}, {"from": "529fbc6c-…

source_5acf6c7b4a664271

{"contradictions": ["The conclusion is that NAD+ metabolism effects remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Signal-accounting note: biomarker-positive source-level findings are separated from clinical-endpoint mixed/null rows; biomarker el…

source_344272404e114010

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The NAD-brain pharmacokinetic study of NAD augmentation in blood and brain using oral precursor supplementation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-ter…

source_af686e90723447e4

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "529fbc6c-66ad-49b5-910a-f2b076cb190c", "sources": [{"directness": "primary", "doi": "10.1016/j.isci.2026.114764", "risk_of_bias": "not appraised in public sidecar", "study": "The NAD-brain pharmacokinetic study of NAD augmentation in blo…

source_22c51e168dc947c9

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}