Derivation Web

claim_77f371e841614606

# Research Synthesis: NAD+ Metabolism Effects — full paper

## Abstract

Evidence-honesty note: 8/12 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement th…

source_e6faafdda7f64280

# Research Synthesis: NAD+ Metabolism Effects — full paper

## Abstract

Evidence-honesty note: 8/12 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement th…

source_15109964045b48d0

{"publication_id": "409d864f-0ec9-426f-a90e-da69e4fd0671", "traces": [{"candidate_sources": [{"doi": "10.1038/s41598-023-29787-3", "study": "Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial", "url": "https://doi.org/10.1038/s41598-023-29787-3"}, {"doi": "10.1093/jn/n…

source_aaee238319f94bc5

{"content_hash": "sha256:ef691aabdb0213050894362550b0b406e30a1ec6169474513336627cec32ce0f", "edges": [{"from": "409d864f-0ec9-426f-a90e-da69e4fd0671", "to": "claim_1", "type": "contains_claim"}, {"from": "409d864f-0ec9-426f-a90e-da69e4fd0671", "to": "claim_2", "type": "contains_claim"}, {"from": "409d864f-0ec9-426f-a90e-da69e4fd0671", "to": "claim_3", "type": "contains_claim"}, {"from": "409d864f-…

source_0d2733a21c3148a4

{"contradictions": ["The conclusion is that NAD+ metabolism effects should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Several mechanistically appealing but clinically actionable effects — for example, the ARDS-ferroptosis link in …

source_87e8bf47ae614465

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD + -Pre…

source_084d8fb7ca5442ed

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "409d864f-0ec9-426f-a90e-da69e4fd0671", "sources": [{"directness": "primary", "doi": "10.1038/s41598-023-29787-3", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide adenine dinucleotide metabolism and arterial stif…

source_c4a87516501c40dc

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}