Derivation Web

claim_947490031c514779

# Adjacent Evidence Brief: Growth differentiation factor 11 — full paper
## Abstract

Evidence-honesty note: 31/48 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not …

source_1e3872458f434c18

# Adjacent Evidence Brief: Growth differentiation factor 11 — full paper
## Abstract

Evidence-honesty note: 31/48 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not …

source_bf3affd2a48f4e55

{"publication_id": "12edec41-aa8d-4c5c-9df1-807b8847f8a1", "traces": [{"candidate_sources": [{"doi": "10.1038/s41467-023-43292-1", "study": "GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21", "url": "https://doi.org/10.1038/s41467-023-43292-1"}, {"doi": "10.1007/s10522-022-09967-w", "study": "Dietary intake of GDF11 delays the onset of several biomarkers of aging in ma…

source_73c7a976a52e4f21

{"content_hash": "sha256:75c66245c46ecb0ae1f4f96eaaf6b73aa56bcdc0b2db5afe4142a8b8a0d95a43", "edges": [{"from": "12edec41-aa8d-4c5c-9df1-807b8847f8a1", "to": "claim_1", "type": "contains_claim"}, {"from": "12edec41-aa8d-4c5c-9df1-807b8847f8a1", "to": "claim_2", "type": "contains_claim"}, {"from": "12edec41-aa8d-4c5c-9df1-807b8847f8a1", "to": "claim_3", "type": "contains_claim"}, {"from": "12edec41-…

source_31d94f23455e4c27

{"contradictions": ["Positive study-level signals are not the dominant direction in any outcome class; null signals are summarized in the contextual adjacent evidence, cardiometabolic, and muscle function outcome classes; negative signals are not the dominant direction in any outcome class; mixed or heterogeneous signals are summarized in the mechanism, mortality and survival, frailty, and immune …

source_01bdda8ac57f4b29

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via …

source_523f23b384874bc3

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "12edec41-aa8d-4c5c-9df1-807b8847f8a1", "sources": [{"directness": "primary", "doi": "10.1038/s41467-023-43292-1", "risk_of_bias": "not appraised in public sidecar", "study": "GDF11 slows excitatory neuronal senescence and brain ageing by…

source_cdd44e022b7a44dd

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}