Derivation Web

claim_9e3e39531cec4f20

# Hypothesis-Generating Brief: Urolithin A — full paper

## Abstract

This paper synthesizes evidence on Urolithin A across 47 accepted source papers and 1415 high-confidence extracted claims.

The evidence profile contains 4 direct clinical sources, 40 adjacent clinical sources, and 3 mechanistic or model-system sources, with a high-density pairwise disagreement map across the evidence base.

Pos…

source_978db9a6268c4dea

# Hypothesis-Generating Brief: Urolithin A — full paper

## Abstract

This paper synthesizes evidence on Urolithin A across 47 accepted source papers and 1415 high-confidence extracted claims.

The evidence profile contains 4 direct clinical sources, 40 adjacent clinical sources, and 3 mechanistic or model-system sources, with a high-density pairwise disagreement map across the evidence base.

Pos…

source_c14fdde48a59402a

{"publication_id": "618b0782-af49-4bf8-95d3-3086702ce350", "traces": [{"candidate_sources": [{"doi": "10.1016/j.xcrm.2022.100633", "study": "Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults", "url": "https://doi.org/10.1016/j.xcrm.2022.100633"}, {"doi": "10.1007/s40279-025-02292-5", "study": "Evaluating t…

source_d7a32851d30842ca

{"content_hash": "sha256:78a4520740a6f7cfecef2fc012ec7e674926c4eaf72cc6866ee23dc4b6082c45", "edges": [{"from": "618b0782-af49-4bf8-95d3-3086702ce350", "to": "claim_1", "type": "contains_claim"}, {"from": "618b0782-af49-4bf8-95d3-3086702ce350", "to": "claim_2", "type": "contains_claim"}, {"from": "618b0782-af49-4bf8-95d3-3086702ce350", "to": "claim_3", "type": "contains_claim"}, {"from": "618b0782-…

source_f5beb152fdcd4d77

{"contradictions": ["The conclusion is that Urolithin A remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The geroscience hypothesis underlying the current wave of anti-aging drug development proposes that a single molecule acting on a shared mec…

source_c0768783b20f4ce5

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Evaluating the Impact of Urolithin A Supplementat…

source_08b2c46a2ad84683

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "618b0782-af49-4bf8-95d3-3086702ce350", "sources": [{"directness": "primary", "doi": "10.1016/j.xcrm.2022.100633", "risk_of_bias": "not appraised in public sidecar", "study": "Urolithin A improves muscle strength, exercise performance, an…

source_065935de090947fe

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}