Derivation Web

claim_b0e3f533f2c242fd

# Adjacent Evidence Brief: Longevity vitamin — full paper

## Abstract

This paper synthesizes evidence on Longevity vitamin across 22 accepted source papers and 559 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 18 adjacent clinical sources, and 4 mechanistic or model-system sources, with 15 cross-study disagreements a…

source_2ad7d1b1ab8841aa

# Adjacent Evidence Brief: Longevity vitamin — full paper

## Abstract

This paper synthesizes evidence on Longevity vitamin across 22 accepted source papers and 559 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 18 adjacent clinical sources, and 4 mechanistic or model-system sources, with 15 cross-study disagreements a…

source_e18ef8a0d78a4523

{"publication_id": "49fee64b-298a-43fc-b595-36c94c769e98", "traces": [{"candidate_sources": [{"doi": "10.1007/s11357-024-01111-5", "study": "Ergothioneine promotes longevity and healthy aging in male mice", "url": "https://doi.org/10.1007/s11357-024-01111-5"}, {"doi": "10.3389/fnut.2026.1835714", "study": "Ergothioneine-rich water extracts of Hericium erinaceus HE-17 alleviate Alzheimer’s disease …

source_118826712f7744c8

{"content_hash": "sha256:82b30641b55126e85441d2cec5b44e2f1cd5859db2cd76287d0171b6714c01ef", "edges": [{"from": "49fee64b-298a-43fc-b595-36c94c769e98", "to": "claim_1", "type": "contains_claim"}, {"from": "49fee64b-298a-43fc-b595-36c94c769e98", "to": "claim_2", "type": "contains_claim"}, {"from": "49fee64b-298a-43fc-b595-36c94c769e98", "to": "claim_3", "type": "contains_claim"}, {"from": "49fee64b-…

source_0c7bc8e81798489a

{"contradictions": ["The conclusion is that Longevity vitamin remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "In animal/preclinical evidence, a defining limitation of this synthesis is the near-total absence of long-term, hard-outcome randomized t…

source_94633306253d4721

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Ergothioneine promotes longevity and healthy aging in male mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Ergothioneine-rich water extracts of Hericium erinaceus HE-17 alleviate Alzheimer’s disease in mice by regulating oxidative stress…

source_6e64525fb990461c

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "49fee64b-298a-43fc-b595-36c94c769e98", "sources": [{"directness": "primary", "doi": "10.1007/s11357-024-01111-5", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine promotes longevity and healthy aging in male mic…

source_39cfa4eaf3b14363

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}