Derivation Web

claim_ddf5a1949bc84782

# Alpha memo — exercise

**Headline:** Exercise signals are endpoint-specific, not uniformly generalizable
**Alpha score:** 100/100 (internal triage score; not a certainty claim)
**Confidence:** `evidence_backed_signal`
**Memo surface:** `broad alpha memo`
**Source scope:** 16 A/B-bound receipts across 10 evidence sources; 12 total references in the source bundle. Two source-bundle entries are cor…

source_7108372e23f54c23

# Alpha memo — exercise

**Headline:** Exercise signals are endpoint-specific, not uniformly generalizable
**Alpha score:** 100/100 (internal triage score; not a certainty claim)
**Confidence:** `evidence_backed_signal`
**Memo surface:** `broad alpha memo`
**Source scope:** 16 A/B-bound receipts across 10 evidence sources; 12 total references in the source bundle. Two source-bundle entries are cor…

source_ba9093b65ce44a06

{"publication_id": "3b113aa9-b186-46fc-b8f4-57f813513544", "traces": [{"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumo…

source_58ffe0df815a4032

{"content_hash": null, "edges": [{"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_1", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_2", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_3", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_4", "type": "contains_clai…

source_ee8b0a8578ba41ec

{"contradictions": ["The common story treats exercise as a single beneficial geroscience intervention. This evidence map says the more useful signal is specificity: different populations, endpoints, and mechanisms move differently, so the publishable claim is not “exercise works,” but “exercise signals need endpoint- and context-specific interpretation.”", "`fact_id=12572` (`A_core`) — Mixed-muscl…

source_d615de54d8f541c3

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exercise-Induced Catecholamines Activate the Hippo Tumor S…

source_ebfd6aaf8e904705

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "3b113aa9-b186-46fc-b8f4-57f813513544", "sources": [{"directness": "primary", "doi": "10.1152/ajpendo.00600.2013", "risk_of_bias": "not appraised in public sidecar", "study": "Activation of mTORC1 signaling and protein synthesis in human …

source_f13209bfacff48ce

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}