Derivation Web

claim_e4c9292fd6da4a72

# Adjacent Evidence Brief: Sulforaphane NRF2 — full paper
## Abstract

This synthesis tests the thesis that evidence for Sulforaphane NRF2 is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indirect, review…

source_b340084d875344be

# Adjacent Evidence Brief: Sulforaphane NRF2 — full paper
## Abstract

This synthesis tests the thesis that evidence for Sulforaphane NRF2 is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indirect, review…

source_744bdaaae86846d8

{"publication_id": "c67a74c0-4be2-4dfe-9638-ee889fd68d14", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1126/sciadv.aed2478", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway", "support_kind…

source_269ee39cd8ae4532

{"content_hash": "sha256:40dfc9e68b0bcdeb1513c586a5d6f1b21b6dbad1495ee9da74a807610f9ced84", "edges": [{"from": "c67a74c0-4be2-4dfe-9638-ee889fd68d14", "to": "claim_1", "type": "contains_claim"}, {"from": "c67a74c0-4be2-4dfe-9638-ee889fd68d14", "to": "claim_2", "type": "contains_claim"}, {"from": "c67a74c0-4be2-4dfe-9638-ee889fd68d14", "to": "claim_3", "type": "contains_claim"}, {"from": "c67a74c0-…

source_312ee112ff7a4e64

{"contradictions": ["Positive study-level signals are not the dominant direction in any outcome class; null signals are not the dominant direction in any outcome class; negative signals are not the dominant direction in any outcome class; mixed or heterogeneous signals are summarized in the contextual adjacent evidence, immune and inflammation, mechanism, and cardiometabolic outcome classes. The p…

source_590aa239c1884d56

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 s…

source_abd076a2680e46c0

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "c67a74c0-4be2-4dfe-9638-ee889fd68d14", "sources": [{"directness": "primary", "doi": "10.1126/sciadv.aed2478", "risk_of_bias": "not appraised in public sidecar", "study": "The skeletal muscle slow myosin heavy chain regulates mammalian me…

source_a701584ed94b4de1

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}